Liu Jiaping, Zhang Yaqiong, Liu Wenwen, Gao Boyan, Yu Liangli Lucy
Institute of Food and Nutraceutical Science, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
China-Canada Joint Lab of Food Nutrition and Health (Beijing), Beijing Technology & Business University (BTBU), Beijing 100048, China.
Foods. 2021 Nov 11;10(11):2773. doi: 10.3390/foods10112773.
A microbial transglutaminase-induced cross-linked sodium caseinate (MSC) was used to stabilize zein nanoparticles, and the study was to investigate whether zein-MSC nanoparticles (zein-MSC NPs) can be used as an encapsulation carrier for resveratrol. A group of resveratrol-loaded zein-MSC nanoparticles (Res-zein-MSC NPs) with varying zein to Res mass ratios was first prepared. The particle sizes and zeta-potentials were in the ranges from 215.00 to 225.00 nm and from -29.00 to -31.00 mV. The encapsulation efficiency (EE) of Res was also influenced by the zein to Res mass ratio, and the encapsulated Res existed in an amorphous form. The major interactions between Res and zein-MSC NPs were hydrogen bonding and hydrophobic interaction. Furthermore, compared with free Res, the photo-stability and bioaccessibility of Res-zein-MSC NPs were significantly improved. The cellular studies also showed that Res-zein-MSC NPs exhibited lower cytotoxicity and desirable anti-inflammatory activity.
使用微生物转谷氨酰胺酶诱导交联的酪蛋白酸钠（MSC）来稳定玉米醇溶蛋白纳米颗粒，该研究旨在探究玉米醇溶蛋白-MSC纳米颗粒（zein-MSC NPs）是否可作为白藜芦醇的包封载体。首先制备了一组具有不同玉米醇溶蛋白与白藜芦醇质量比的负载白藜芦醇的玉米醇溶蛋白-MSC纳米颗粒（Res-zein-MSC NPs）。粒径和zeta电位范围分别为215.00至225.00 nm和-29.00至-31.00 mV。白藜芦醇的包封效率（EE）也受玉米醇溶蛋白与白藜芦醇质量比的影响，且包封的白藜芦醇以无定形形式存在。白藜芦醇与玉米醇溶蛋白-MSC NPs之间的主要相互作用为氢键和疏水相互作用。此外，与游离白藜芦醇相比，Res-zein-MSC NPs的光稳定性和生物可及性显著提高。细胞研究还表明，Res-zein-MSC NPs表现出较低的细胞毒性和良好的抗炎活性。
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