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提取物的抗炎作用：体外和体内模型研究。

Anti-Inflammatory Effects of Extract on In Vitro and In Vivo Models.

机构信息

Department of Physiology, College of Medicine, Chung-Ang University, Seoul 06974, Korea.

Laboratory of Pharmacognosy and Natural Product based Medicine, College of Pharmacy, Chung-Ang University, Seoul 06974, Korea.

出版信息

Molecules. 2020 Mar 20;25(6):1418. doi: 10.3390/molecules25061418.

DOI:10.3390/molecules25061418
PMID:32244969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7145316/
Abstract

extracts (ASex) have long been used in Oriental medicine to treat various conditions. To provide a scientific basis for this application and the underlying mechanism, we investigated the anti-inflammatory effects of ASex in vitro and in vivo. The in vitro model was established using human dermal fibroblasts (HDFs) treated with inflammatory stimulants (lipopolysaccharide, tumor necrosis factor-alpha, interferon-gamma). Lactate dehydrogenase and reverse transcription-polymerase chain reaction showed that ASex inhibited the increased expression of acute-phase inflammatory cytokines. The in vivo model was established by inducing skin inflammation in NC/Nga mice via the repeated application of house dust mite (HDM) ointment to the ears and back of the mice for eight weeks. HDM application increased the severity of skin lesions, eosinophil/mast cell infiltration, and serum immunoglobulin E levels, which were all significantly decreased by ASex treatment, demonstrating the same degree of protection as hydrocortisone. Overall, ASex showed excellent anti-inflammatory effects both in vitro and in vivo, suggesting its potential as an excellent candidate drug to reduce skin inflammation.

摘要

提取物（ASex）长期以来一直被用于东方医学治疗各种病症。为了为这种应用及其潜在机制提供科学依据，我们研究了 ASex 的抗炎作用在体外和体内。体外模型是使用炎性刺激物（脂多糖、肿瘤坏死因子-α、干扰素-γ）处理的人真皮成纤维细胞（HDF）建立的。乳酸脱氢酶和逆转录聚合酶链反应显示，ASex 抑制了急性期炎症细胞因子的表达增加。体内模型是通过将屋尘螨（HDM）软膏反复涂抹于 NC/Nga 小鼠的耳朵和背部 8 周来诱导皮肤炎症建立的。HDM 应用增加了皮肤病变、嗜酸性粒细胞/肥大细胞浸润和血清免疫球蛋白 E 水平的严重程度，ASex 治疗均显著降低，与氢化可的松的保护程度相同。总体而言，ASex 在体外和体内均表现出出色的抗炎作用，表明其具有成为减轻皮肤炎症的优秀候选药物的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/7145316/70a617d4eca8/molecules-25-01418-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/7145316/cdb0e28c2a52/molecules-25-01418-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/7145316/711c4be5ac51/molecules-25-01418-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/7145316/9bb37f66d03e/molecules-25-01418-g009a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/7145316/67222acfe1a2/molecules-25-01418-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/7145316/70a617d4eca8/molecules-25-01418-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/7145316/82acfc88b358/molecules-25-01418-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/7145316/7196934edef2/molecules-25-01418-g007.jpg
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