Low expression of is associated with favorable prognosis and sensitivity to radiation/pharmaceutical therapy in lower grade glioma.

: is overexpressed in multiple cancers including malignant glioma and contributes to different cellular processes. However, little attention has been paid to the lower grade glioma (LGG).: Cox coefficients were examined to compare expression among different tumors types using OncoLnc. The UCSC Xena browser was used to generate Kaplan-Meier survival curves and explore the association between expression and overall survival (OS) in TCGA-LGG and subgroups.: expression in LGG was ranked first among 21 different cancers. LGG with lower expression had longer OS ( < 0.001). The astrocytoma group had the highest expression and shortest OS, followed by oligoastrocytoma and oligodendroglioma ( < 0.05). The 1p19q co-deletion or mutation subgroups had lower expression and longer OS ( < 0.001). Compared with the corresponding groups, LGG with lower expression had longer OS than the following groups: astrocytoma, oligodendroglioma, with/without 1p19q co-deletion, with mutation, with radiation, and with pharmaceutical therapy ( < 0.05).: is a prognostic marker in LGG and subgroups.