Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Neurol Res. 2020 Jun;42(6):522-527. doi: 10.1080/01616412.2020.1748323. Epub 2020 Apr 3.
: is overexpressed in multiple cancers including malignant glioma and contributes to different cellular processes. However, little attention has been paid to the lower grade glioma (LGG).: Cox coefficients were examined to compare expression among different tumors types using OncoLnc. The UCSC Xena browser was used to generate Kaplan-Meier survival curves and explore the association between expression and overall survival (OS) in TCGA-LGG and subgroups.: expression in LGG was ranked first among 21 different cancers. LGG with lower expression had longer OS ( < 0.001). The astrocytoma group had the highest expression and shortest OS, followed by oligoastrocytoma and oligodendroglioma ( < 0.05). The 1p19q co-deletion or mutation subgroups had lower expression and longer OS ( < 0.001). Compared with the corresponding groups, LGG with lower expression had longer OS than the following groups: astrocytoma, oligodendroglioma, with/without 1p19q co-deletion, with mutation, with radiation, and with pharmaceutical therapy ( < 0.05).: is a prognostic marker in LGG and subgroups.
在包括恶性神经胶质瘤在内的多种癌症中过度表达，并有助于多种细胞过程。然而，低级别神经胶质瘤（LGG）很少受到关注。
使用 OncoLnc 检查 Cox 系数以比较不同肿瘤类型中的表达。使用 UCSC Xena 浏览器生成 Kaplan-Meier 生存曲线，并探索 TCGA-LGG 和亚组中表达与总生存期（OS）之间的关联。
在 21 种不同癌症中，LGG 中的表达排名第一。表达较低的 LGG 具有更长的 OS（<0.001）。星形细胞瘤组表达最高，OS 最短，其次是少突星形细胞瘤和少突胶质细胞瘤（<0.05）。1p19q 共缺失或突变亚组的表达较低，OS 较长（<0.001）。与相应的组相比，表达较低的 LGG 具有比以下组更长的 OS：星形细胞瘤、少突胶质细胞瘤、具有/不具有 1p19q 共缺失、具有突变、具有放射治疗和具有药物治疗（<0.05）。
是 LGG 和亚组的预后标志物。
