EYA4 在 IDH1 突变伴 1p19q 共缺失的低级别胶质瘤中的预后作用。

Prognostic Role of EYA4 in Lower Grade Glioma with IDH1 Mutation and 1p19q Co-Deletion.

机构信息

Department of Functional Neurosurgery, Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

School of Clinical Medicine, Tsinghua University, Beijing, China.

出版信息

World Neurosurg. 2021 May;149:e1174-e1179. doi: 10.1016/j.wneu.2020.07.094. Epub 2021 Feb 23.

DOI:10.1016/j.wneu.2020.07.094

PMID:33631386

Abstract

BACKGROUND

Eyes absent 4 (EYA4) participates in an important role in various cancers. Patients with low EYA4 expression have significantly favorable prognosis compared with those with high EYA4 expression. However, the expression and role of EYA4 in lower grade glioma (LGG) has not been fully elucidated.

METHODS

The R2 and UCSC Xena browser based on data from 284 cases in GSE16011 from Gene Expression Omnibus datasets and 530 cases of patients with LGG in The Cancer Genome Atlas database were extracted for bioinformatic analyses. The EYA4 expression in different subtypes of LGG was detected. Kaplan-Meier survival curves were generated to explore the association between EYA4 expression and overall survival (OS) in both datasets.

RESULTS

Patients with LGG with lower EYA4 expression had significantly longer 5- and 10-year OS in 2 datasets (P < 0.001). By matching histological subtypes and gene expression profiles of patients with LGG, oligoastrocytoma and oligodendroglioma groups had lower EYA4 expression and longer OS compared with the astrocytoma group (P < 0.05). Patients with IDH1 mutations and 1p19q co-deletion had longer 5- and 10-year OS (P < 0.001), and EYA4 expression was significantly downregulated in these patients (P < 0.001).

CONCLUSIONS

This study suggests that EYA4 can be used as a prognostic marker and provide a potential therapeutic target in patients with LGG with IDH1 mutation and 1p19q co-deletion.

摘要

背景

眼睛缺失 4 蛋白（EYA4）在多种癌症中发挥重要作用。与高 EYA4 表达的患者相比，低 EYA4 表达的患者具有显著更有利的预后。然而，EYA4 在低级别胶质瘤（LGG）中的表达和作用尚未完全阐明。

方法

从基因表达综合数据库（GEO）GSE16011 中包含的 284 例病例和癌症基因组图谱（TCGA）数据库中包含的 530 例 LGG 患者的数据中提取 R2 和 UCSC Xena 浏览器进行生物信息学分析。检测不同 LGG 亚型中 EYA4 的表达。绘制 Kaplan-Meier 生存曲线，以探索这两个数据集之间 EYA4 表达与总生存期（OS）之间的关联。

结果

在这两个数据集，LGG 患者中 EYA4 表达水平较低的患者具有显著更长的 5 年和 10 年 OS（P<0.001）。通过匹配 LGG 患者的组织学亚型和基因表达谱，少突星形细胞瘤和少突胶质细胞瘤组的 EYA4 表达水平较低，OS 较长，与星形细胞瘤组相比差异具有统计学意义（P<0.05）。IDH1 突变和 1p19q 共缺失的患者具有更长的 5 年和 10 年 OS（P<0.001），这些患者的 EYA4 表达明显下调（P<0.001）。