The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510700, Guangdong, China.
The State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China.
J Nanobiotechnology. 2020 Apr 3;18(1):57. doi: 10.1186/s12951-020-00612-7.
Intolerable toxicity and unsatisfactory therapeutic effects are still big problems retarding the use of chemotherapy against cancer. Nano-drug delivery system promised a lot in increasing the patients' compliance and therapeutic efficacy. As a unique nano-carrier, supermolecular aggregation nanovehicle has attracted increasing interests due to the following advantages: announcing drug loading efficacy, pronouncing in vivo performance and simplified production process.
In this study, the supermolecular aggregation nanovehicle of bortezomib (BTZ) was prepared to treat breast cancer.
Although many supermolecular nanovehicles are inclined to disintegrate due to the weak intermolecular interactions among the components, the BTZ supermolecules are satisfying stable. To shed light on the reasons behind this, the forces driving the formation of the nanovehicles were detailed investigated. In other words, the interactions among BTZ and other two components were studied to characterize the nanovehicles and ensure its stability.
Due to the promising tumor targeting ability of the BTZ nanovehicles, the supermolecule displayed promising tumor curing effects and negligible systemic toxicity.
难以忍受的毒性和不理想的治疗效果仍然是阻碍癌症化疗应用的大问题。纳米药物递送系统有望提高患者的顺应性和治疗效果。作为一种独特的纳米载体，超分子聚集纳米载体由于以下优点而引起了越来越多的关注：宣布药物负载功效、宣布体内性能和简化生产工艺。
本研究制备了硼替佐米（BTZ）的超分子聚集纳米载体来治疗乳腺癌。
尽管许多超分子纳米载体由于组成成分之间的弱分子间相互作用而倾向于分解，但 BTZ 超分子却非常稳定。为了揭示背后的原因，详细研究了驱动纳米载体形成的力。换句话说，研究了 BTZ 与其他两种成分之间的相互作用，以表征纳米载体并确保其稳定性。
由于 BTZ 纳米载体具有有前途的肿瘤靶向能力，超分子显示出有前途的肿瘤治疗效果和可忽略的全身毒性。
