Waleka Ewelina, Stojek Zbigniew, Karbarz Marcin
Faculty of Chemistry, Biological and Chemical Research Center, University of Warsaw, 101 Żwirki i Wigury Av., PL 02-089 Warsaw, Poland.
Faculty of Chemistry, Warsaw University of Technology, 1 Pl. Politechniki Av., PL 00-661 Warsaw, Poland.
Pharmaceutics. 2021 May 4;13(5):654. doi: 10.3390/pharmaceutics13050654.
Due to the unwanted toxic properties of some drugs, new efficient methods of protection of the organisms against that toxicity are required. New materials are synthesized to effectively disseminate the active substance without affecting the healthy cells. Thus far, a number of polymers have been applied to build novel drug delivery systems. One of interesting polymers for this purpose is povidone, pVP. Contrary to other polymeric materials, the synthesis of povidone nanoparticles can take place under various condition, due to good solubility of this polymer in several organic and inorganic solvents. Moreover, povidone is known as nontoxic, non-carcinogenic, and temperature-insensitive substance. Its flexible design and the presence of various functional groups allow connection with the hydrophobic and hydrophilic drugs. It is worth noting, that pVP is regarded as an ecofriendly substance. Despite wide application of pVP in medicine, it was not often selected for the production of drug carriers. This review article is focused on recent reports on the role povidone can play in micro- and nano drug delivery systems. Advantages and possible threats resulting from the use of povidone are indicated. Moreover, popular biomedical aspects are discussed.
由于某些药物具有不良毒性，因此需要新的有效方法来保护机体免受这种毒性影响。人们合成新型材料以有效分散活性物质而不影响健康细胞。迄今为止，许多聚合物已被用于构建新型药物递送系统。用于此目的的一种有趣聚合物是聚维酮，即PVP。与其他聚合物材料不同，由于该聚合物在几种有机和无机溶剂中具有良好的溶解性，聚维酮纳米颗粒的合成可以在各种条件下进行。此外，聚维酮是无毒、无致癌性且对温度不敏感的物质。其灵活的结构和各种官能团的存在使得它能够与疏水性和亲水性药物连接。值得注意的是，PVP被视为一种环保物质。尽管PVP在医学上有广泛应用，但它并不常被选用于生产药物载体。这篇综述文章聚焦于聚维酮在微米和纳米药物递送系统中所起作用的最新报道。文中指出了使用聚维酮带来的优点和可能的风险。此外，还讨论了常见的生物医学方面的问题。
