Mozdarani Hossein, Ezzatizadeh Vahid, Rahbar Parvaneh Roghayeh
Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
J Transl Med. 2020 Apr 3;18(1):152. doi: 10.1186/s12967-020-02320-0.
Despite considering vast majority of the transcribed molecules as merely noise RNA in the last decades, recent advances in the field of molecular biology revealed the mysterious role of long non-coding RNAs (lncRNAs), as a massive part of functional non-protein-coding RNAs. As a crucial lncRNA, HOX antisense intergenic RNA (HOTAIR) has been shown to participate in different processes of normal cell development. Aberrant overexpression of this lncRNA contributes to breast cancer progression, through different molecular mechanisms. In this review, we briefly discuss the structure of HOTAIR in the context of genome and impact of this lncRNA on normal human development. We subsequently summarize the potential role of HOTAIR overexpression on different processes of breast cancer development. Ultimately, the relationship of this lncRNA with different therapeutic approaches is discussed.
在过去几十年里，尽管绝大多数转录分子仅被视为噪音RNA，但分子生物学领域的最新进展揭示了长链非编码RNA（lncRNAs）的神秘作用，它们是功能性非蛋白质编码RNA的重要组成部分。作为一种关键的lncRNA，HOX反义基因间RNA（HOTAIR）已被证明参与正常细胞发育的不同过程。这种lncRNA的异常过表达通过不同的分子机制促进乳腺癌进展。在这篇综述中，我们简要讨论了HOTAIR在基因组背景下的结构以及该lncRNA对正常人类发育的影响。随后，我们总结了HOTAIR过表达在乳腺癌发展不同过程中的潜在作用。最后，讨论了这种lncRNA与不同治疗方法的关系。
