Gosia Meeral, Doshi Gaurav, Parab Siddhi, Godad Angel
Department of Pharmacology, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, V L M Road, Vile Parle, Mumbai, 400056, India.
Reprod Sci. 2025 Aug 15. doi: 10.1007/s43032-025-01948-x.
Gynaecologic cancer is a major cause of death for women and the most well-known ovarian cancer (OC) has a high mortality rate. Given that the majority of ovarian cancer deaths are caused by metastatic tumors that have spread to nearby tissues, several biological processes, including angiogenesis and metastasis, have a role in the onset and course of these diseases. Numerous non-coding RNAs (ncRNAs) have been shown in recent studies to contribute to the invasion and metastasis of ovarian cancer by altering particular cellular pathways. Three forms of ncRNAs which are long non-coding RNAs, micro RNAs, and circular RNAs are the subjects of this review. miRNA is used as a potential biomarker such as miR-375 which is a serum exosome and also in therapeutics. lncRNA sponges with miRNA which sequesters and regulates tumor progression such as XIST miR-149-3p. circRNA targets proteins and regulates gene expression. This review provides an overview of the precise function of non-coding RNAs in the many pathways and molecular exchanges that contribute to the invasion and metastasis of malignancies. To increase the survival rate of OC patients, new approaches to ncRNA-targeted therapy are being utilised, including targeting lncRNAs and circRNAs and modulating the tumor microenvironment using exosomes.
妇科癌症是女性死亡的主要原因，最广为人知的卵巢癌（OC）死亡率很高。鉴于大多数卵巢癌死亡是由扩散到附近组织的转移性肿瘤引起的，包括血管生成和转移在内的几种生物学过程在这些疾病的发生和发展过程中发挥作用。最近的研究表明，许多非编码RNA（ncRNAs）通过改变特定的细胞途径促进卵巢癌的侵袭和转移。本文综述的三种ncRNAs形式为长链非编码RNA、微小RNA和环状RNA。miRNA被用作潜在的生物标志物，如血清外泌体中的miR-375，也用于治疗。lncRNA与miRNA结合，隔离并调节肿瘤进展，如XIST与miR-149-3p。circRNA靶向蛋白质并调节基因表达。本文综述了非编码RNA在导致恶性肿瘤侵袭和转移的多种途径和分子交换中的精确功能。为了提高OC患者的生存率，正在采用新的ncRNA靶向治疗方法，包括靶向lncRNAs和circRNAs以及使用外泌体调节肿瘤微环境。
