Department of Internal Medicine, Robert Wood Johnson School of Medicine, 1 Robert Wood Johnson Place, New Brunswick, NJ 08901, USA.
Center for Liver Diseases and Liver Masses, Robert Wood Johnson School of Medicine, MedEd Building, Room 466, 1 Robert Wood Johnson Place, New Brunswick, NJ 08901, USA.
Clin Liver Dis. 2020 May;24(2):231-242. doi: 10.1016/j.cld.2020.01.005. Epub 2020 Mar 2.
Pharmacologic management of hepatic encephalopathy includes a broad range of therapies. This article covers the specific mainstays of therapies, such as antimicrobials and laxatives, with an established evidence base. This article also covers newer modalities of therapies, such as fecal microbiota transplant, probiotics, bioartificial support systems, small molecular therapies such as l-ornithine l-aspartate, branched chain amino acids, l-carnitine, zinc, and other forms of therapy currently under review.
肝性脑病的药物治疗包括广泛的治疗方法。本文涵盖了具有既定证据基础的特定治疗方法,如抗生素和泻药。本文还涵盖了一些较新的治疗方法,如粪便微生物移植、益生菌、生物人工支持系统、小分子治疗药物,如 l-鸟氨酸 l-天冬氨酸、支链氨基酸、左旋肉碱、锌等,以及其他正在审查中的治疗方法。