I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Bull Exp Biol Med. 2020 Mar;168(5):614-617. doi: 10.1007/s10517-020-04763-3. Epub 2020 Apr 4.
The effects of acclimatization to middle attitude hypoxia on the resistance to acute emotional stress were studied on the model of posttraumatic stress disorder in rats. Anxyolitic, but not anxiogenic effect was observed in acclimatized rats. However, acclimatized rats with posttraumatic stress disorder were characterized by hypofunction of the pituitary-adrenocortical axis, which is typical of this pathology, and reduction in corticosterone/dehydroepiandrosterone ratio. At the neuroendocrine level, up-regulation of glucocorticoid receptors and a decrease in the level of corticotropin-releasing hormone in the hippocampus were revealed. The observed modifications of regulatory mechanisms can underlie hypofunction of the pituitary-adrenocortical axis. It was concluded that acclimatization to middle attitude hypoxia masks behavioral symptoms of posttraumatic stress disorder, but does not alter its pathogenetic neuroendocrine mechanisms.
研究了适应中等海拔缺氧对抵抗急性情绪应激的影响，建立了创伤后应激障碍大鼠模型。结果发现，适应组大鼠表现出抗焦虑作用，而不是焦虑作用。然而，适应组伴创伤后应激障碍的大鼠表现出促肾上腺皮质激素轴功能低下，这是该病理的典型特征，同时皮质酮/脱氢表雄酮比值降低。在神经内分泌水平上，发现海马中糖皮质激素受体上调，促肾上腺皮质激素释放激素水平降低。观察到的调节机制的改变可能是促肾上腺皮质激素轴功能低下的基础。结论是，适应中等海拔缺氧可以掩盖创伤后应激障碍的行为症状，但不改变其发病的神经内分泌机制。
