Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei City 11490, Taiwan.
Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan.
Int J Environ Res Public Health. 2023 Feb 6;20(4):2868. doi: 10.3390/ijerph20042868.
We aim to explore if there is a relationship between acute mountain sickness (AMS) and the risk of psychiatric disorders in Taiwan by using the National Health Insurance Research Database for to the rare studies on this topic. We enrolled 127 patients with AMS, and 1270 controls matched for sex, age, monthly insured premiums, comorbidities, seasons for medical help, residences, urbanization level, levels of care, and index dates were chosen from 1 January 2000 to 31 December 2015. There were 49 patients with AMS and 140 controls developed psychiatric disorders within the 16-year follow-up. The Fine-Gray model analyzed that the patients with AMS were prone to have a greater risk for the development of psychiatric disorders with an adjusted sub-distribution hazard ratio (sHRs) of 10.384 (95% confidence interval [CI]: 7.267-14.838, < 0.001) for psychiatric disorders. The AMS group was associated with anxiety disorders, depressive disorders, bipolar disorder, sleep disorders, posttraumatic stress disorder/acute stress disorder, psychotic disorder, and substance-related disorder (SRD). The relationship between anxiety, depression, sleep disorders, SRD, and AMS still persisted even after we excluded the psychiatric disorders within the first five years after AMS. There was an association between AMS and the rising risk of psychiatric disorders in the 16 years of long-term follow-up research.
我们旨在利用台湾全民健康保险研究数据库探索急性高山病（AMS）与精神障碍风险之间是否存在关系，以填补该主题罕见研究的空白。我们招募了 127 例 AMS 患者和 1270 例性别、年龄、月保险费、合并症、就医季节、居住地、城市化水平、护理水平和索引日期匹配的对照者，这些患者均来自 2000 年 1 月 1 日至 2015 年 12 月 31 日。在 16 年的随访中，有 49 例 AMS 患者和 140 例对照者发展为精神障碍。Fine-Gray 模型分析表明，AMS 患者发生精神障碍的风险更高，调整后的亚分布风险比（sHR）为 10.384（95%置信区间[CI]：7.267-14.838，<0.001）。AMS 组与焦虑障碍、抑郁障碍、双相情感障碍、睡眠障碍、创伤后应激障碍/急性应激障碍、精神病性障碍和物质相关障碍（SRD）有关。即使排除 AMS 后 5 年内的精神障碍后，AMS 与焦虑、抑郁、睡眠障碍、SRD 之间仍存在关联。在 16 年的长期随访研究中，AMS 与精神障碍风险的增加存在关联。
