Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China.
Department of Plant Pathology, China Agricultural University, Beijing, China.
Pest Manag Sci. 2020 Aug;76(8):2829-2837. doi: 10.1002/ps.5833. Epub 2020 May 4.
The development of efficient and safe green pesticides is a scientific strategy to alleviate current pesticide residues, environmental pollution, and threats to non-target organisms. Pesticide controlled-release formulations (CRFs) have attracted wide attention because they can control the rate of release of active ingredients and prolong the effective duration. In particular, nanoscale pesticide sustained-release systems have excellent biological activity and distribution performance because of their small particle size. Some technical difficulties remain in obtaining nanoscale CRFs.
We successfully fabricated pyraclostrobin nanosphere CRF by combining high-pressure homogenization technology and emulsion-solvent evaporation methods. The pyraclostrobin nanospheres had a uniform spherical shape with a mean particle size of 450 nm and polydispersity index of less than 0.3. The pyraclostrobin loading capacity reached 53.6%, with excellent storage stability. The contact angle of nanospheres on cucumber leaf surfaces demonstrated that it had good wettability. Compared with pyraclostrobin technical and commercial formulations, the nanosphere systems showed a significantly sustained release of pyraclostrobin for longer (up to 250 h). A preliminary bioassay against Penicillium ochrochloron showed that the bioactivity and long-term efficiency of pyraclostrobin nanospheres were superior to those of the commercial formulation.
This research introduced a simple, fast, expandable method for preparing pyraclostrobin nanospheres. The results showed that pyraclostrobin nanospheres could prolong the duration of pesticide efficacy and enhance bioactivity. Furthermore, this technology provides a platform for scale-up production of nano-scale pesticide CRFs. © 2020 Society of Chemical Industry.
开发高效、安全的绿色农药是缓解当前农药残留、环境污染和非靶标生物威胁的科学策略。农药控制释放制剂（CRFs）因其能够控制活性成分的释放速度并延长有效持续时间而受到广泛关注。特别是，纳米级农药缓释系统由于其粒径小，具有优异的生物活性和分布性能。然而，在获得纳米级 CRFs 方面仍存在一些技术难题。
我们成功地通过结合高压匀化技术和乳液-溶剂蒸发方法制备了吡唑醚菌酯纳米球 CRF。吡唑醚菌酯纳米球具有均匀的球形形状，平均粒径为 450nm，多分散指数小于 0.3。吡唑醚菌酯的载药量达到 53.6%，具有良好的储存稳定性。纳米球在黄瓜叶片表面的接触角表明其具有良好的润湿性。与吡唑醚菌酯技术和商业制剂相比，纳米球体系表现出显著的吡唑醚菌酯持续释放更长时间（长达 250h）。对青霉菌的初步生物测定表明，吡唑醚菌酯纳米球的生物活性和长期效率优于商业制剂。
本研究介绍了一种简单、快速、可扩展的制备吡唑醚菌酯纳米球的方法。结果表明，吡唑醚菌酯纳米球可以延长农药药效持续时间并提高生物活性。此外，该技术为纳米级农药 CRFs 的规模化生产提供了一个平台。© 2020 英国化学学会。
