Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, P. R. China.
School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, P. R. China.
Chem Biodivers. 2020 Jun;17(6):e2000111. doi: 10.1002/cbdv.202000111. Epub 2020 May 7.
Two new abietane diterpenoids, (3S,5R,10S)-3-hydroxy-12-O-demethyl-11-deoxy-19(4→3)-abeo-cryptojaponol, 12,19-dihydroxyabieta-8,11,13-trien-7-one, were isolated from Selaginella moellendorffii Hieron., together with one known abietane diterpenoid and four known tetracyclic triterpenoids. Their structures were characterized by their 1D- and 2D-NMR, ECD and mass spectral studies. All compounds were tested for their inhibitory effects on proliferation of three human cancer cells (human non-small-cell lung carcinoma cell lines A549 and human breast adenocarcinoma cell lines MDA-MB-231 and MCF-7) in vitro. Among them, three compounds displayed modest cytotoxic activities against the above three human cancer cell lines with IC values ranging from 16.28 to 40.67 μM.
从卷柏属植物中分离得到了两个新的贝壳杉烷二萜类化合物，(3S,5R,10S)-3-羟基-12-O-去甲基-11-去氧-19(4→3)-abeo-隐孔菌素和 12,19-二羟基贝壳杉-8,11,13-三烯-7-酮，以及一个已知的贝壳杉烷二萜和四个已知的四环三萜。通过 1D-和 2D-NMR、ECD 和质谱研究确定了它们的结构。所有化合物均在体外测试了对三种人癌细胞（人非小细胞肺癌细胞系 A549 和人乳腺癌细胞系 MDA-MB-231 和 MCF-7）增殖的抑制作用。其中，三个化合物对上述三种人癌细胞系具有中等的细胞毒性活性，IC 值范围为 16.28 至 40.67 μM。
