Medicinal Plants Research Centr, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran.
Phytochemistry. 2022 Oct;202:113310. doi: 10.1016/j.phytochem.2022.113310. Epub 2022 Jul 19.
The Phytochemical profiling of the root extract of Salvia leriifolia, an endemic plant of Iran, was investigated and 16 abietane diterpenes were isolated, and three were original compounds. 1D and 2D NMR and HRMS performed structural elucidation. The absolute configuration of the previously unreported compounds was determined by circular dichroism (ECD). The cytotoxicity of the isolated compounds was investigated against AGS, MIA PaCa-2, HeLa, and MCF-7 cell lines by the MTT assay. The known diterpene pisiferal possesses high cytotoxicity against all investigated cell lines at a concentration between 9.3 ± 0.6 and 14.38 ± 1.4 μM.
对伊朗特有植物血水草根提取物的植物化学分析表明，共分离得到 16 个松香烷二萜类化合物，其中 3 个为新化合物。通过 1D 和 2D NMR 以及高分辨质谱（HRMS）完成了结构鉴定。通过圆二色谱（ECD）确定了以前未报道过的化合物的绝对构型。通过 MTT 法测定了分离得到的化合物对 AGS、MIA PaCa-2、HeLa 和 MCF-7 细胞系的细胞毒性。已知的松香烷二萜化合物 pisiferal 对所有检测的细胞系均具有高细胞毒性，在 9.3±0.6 到 14.38±1.4μM 浓度之间。
