来自江西赪桐的生物活性二萜类化合物。
Bioactive Diterpenoids from Clerodendrum kiangsiense.
作者信息
Xu Mingfeng, Wang Shengjia, Jia Ouya, Zhu Qin, Shi Lu'e
机构信息
Zhejiang Provincial Key Laboratory for Genetic Improvement and Quality Control of Medicinal Plants, Hangzhou Normal University, Hangzhou 310036, China.
出版信息
Molecules. 2016 Jan 15;21(1):86. doi: 10.3390/molecules21010086.
A new abeo-abietane diterpenoid, 12-methoxy-6,11,14,16-tetrahydroxy-17(15→16)-abeo-5,8,11,13-abietatetraen-3,7-dione (8), was isolated from the hydroalcoholic extract of the herb of Clerodendrum kiangsiense along with seven known diterpenoids (1-7). Their structures were identified on the basis of spectroscopic analyses including two-dimensional NMR and comparison with literature data. All of these compounds were evaluated for their cytotoxic activities against the growth of human cancer cells lines HL-60, SMMC-7721, A-549 and MCF-7 by the MTT assay. The results showed that cryptojaponol (4), fortunin E (6) and 8 exhibited significant cytotoxicity against four human cancer cell lines.
从江西赪桐全草的水醇提取物中分离得到一个新的去甲枞酸型二萜，12-甲氧基-6,11,14,16-四羟基-17(15→16)-去甲-5,8,11,13-枞四烯-3,7-二酮（8），以及七个已知二萜（1-7）。通过包括二维核磁共振在内的光谱分析并与文献数据进行比较，确定了它们的结构。采用MTT法评价了所有这些化合物对人癌细胞系HL-60、SMMC-7721、A-549和MCF-7生长的细胞毒性活性。结果表明，隐丹参醇（4）、fortunein E（6）和8对四种人癌细胞系表现出显著的细胞毒性。
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