Clinical Department of Obstetrics and Gynecology, Zagreb University Hospital Center, School of Medicine, University of Zagreb, Zagreb, Croatia.
Montauniversitat Leoben, Leoben, Austria.
Int J Gynaecol Obstet. 2020 Jun;149(3):309-317. doi: 10.1002/ijgo.13151. Epub 2020 Apr 27.
To evaluate the concentration and profile of fatty acids (FAs) among macrosomic neonates delivered by healthy pregnant women and pregnant women with type 1 diabetes mellitus (T1DM).
A prospective study of women who delivered macrosomic neonates at a University Hospital Center, Zagreb, Croatia, 2016-2018. Maternal, umbilical vein, and arterial blood samples were collected immediately on delivery. After lipid extraction, total FAs in maternal, umbilical vein, and arterial serum samples were assessed by gas chromatography. Data were compared between women with T1DM and healthy control women.
In total, 50 women were enrolled: 22 with T1DM and 28 control women. Neonates in the T1DM group had a higher ponderal index as compared with the control group (P=0.006). Umbilical vein insulin, insulin resistance, and leptin concentration were higher in the T1DM group than in the control group (all P<0.001). Umbilical vein serum concentrations of total saturated, monounsaturated, n-3 polyunsaturated, and n-6 polyunsaturated FAs were higher in the T1DM group (P=0.004, P<0.001, P=0.015, and P=0.014, respectively).
Macrosomic neonates delivered by women with T1DM had a higher Ponderal index, and higher concentrations of insulin, leptin, and FAs in the umbilical vein and artery as compared with control group newborns.
评估健康孕妇和 1 型糖尿病孕妇所分娩的巨大儿新生儿的脂肪酸（FA）浓度和分布。
这是一项在克罗地亚萨格勒布大学医院中心进行的前瞻性研究，研究对象为 2016 年至 2018 年分娩巨大儿的孕妇。产妇、脐静脉和动脉血样在分娩时立即采集。脂质提取后，采用气相色谱法评估母体、脐静脉和动脉血清样本中的总 FA。将 1 型糖尿病孕妇与健康对照组孕妇的数据进行比较。
共纳入 50 名孕妇，其中 22 名患有 1 型糖尿病，28 名对照组孕妇。与对照组相比，1 型糖尿病组新生儿的体重指数更高（P=0.006）。1 型糖尿病组脐静脉胰岛素、胰岛素抵抗和瘦素浓度均高于对照组（均 P<0.001）。1 型糖尿病组脐静脉血清总饱和、单不饱和、n-3 多不饱和和 n-6 多不饱和 FA 浓度均高于对照组（分别为 P=0.004、P<0.001、P=0.015 和 P=0.014）。
与对照组新生儿相比，1 型糖尿病孕妇所分娩的巨大儿新生儿体重指数更高，脐静脉和动脉中胰岛素、瘦素和 FA 的浓度更高。
