Liu Kaiyong, Ye Kui, Han Yanping, Sheng Jie, Jin Zhongxiu, Bo Qinli, Hu Chunqiu, Hu Chuanlai, Li Li
Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China.
Auhui Provincial Laboratory of Population Health and Eugenics, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China.
Asia Pac J Clin Nutr. 2017 Mar;26(2):291-297. doi: 10.6133/apjcn.012016.11.
This study evaluated the association of maternal excessive gestational weight gain with saturated and polyunsaturated fatty acid concentrations in maternal and cord serum.
We included 77 pairs of women and their newborns and classified them into three groups as follows: mothers with normal gestational weight gain and their babies with normal birth weight in group I (30 pairs), mothers with excessive gestational weight gain and their babies with normal birth weight in group II (30 pairs), and mothers with excessive gestational weight gain and their macrosomic babies in group III (17 pairs). Serum fatty acid concentrations were determined through gas chromatography-mass spectrometry.
No remarkable difference in maternal dietary intake was observed among the three groups. C16:0, C18:0, eicosapentaenoic acid, and docosahexaenoic acid concentrations were significantly higher in group III mothers than in group I mothers. Compared with group I neonates, total saturated and polyunsaturated fatty acid concentrations were significantly lower but total n-3 polyunsaturated fatty acid and docosahexaenoic acid concentrations were significantly higher in group II neonates (p<0.05). The n-6: n-3 ratio in maternal and cord serum was approximately 10:1 and 1.5:1, respectively.
Women with excessive gestational weight gain who deliver a macrocosmic neonate tend to have higher total saturated fatty acid concentrations but lower docosahexaenoic acid concentrations in their neonate cord serum. Fatty acid concentrations in maternal and cord serum are not associated with maternal dietary pattern.
本研究评估了孕妇孕期体重过度增加与孕妇及脐带血清中饱和脂肪酸和多不饱和脂肪酸浓度之间的关联。
我们纳入了77对母婴，并将他们分为以下三组：第一组为孕期体重增加正常且新生儿出生体重正常的母亲及其婴儿（30对），第二组为孕期体重过度增加且新生儿出生体重正常的母亲及其婴儿（30对），第三组为孕期体重过度增加且新生儿为巨大儿的母亲及其婴儿（17对）。通过气相色谱-质谱法测定血清脂肪酸浓度。
三组母亲的膳食摄入量没有显著差异。第三组母亲的C16:0、C18:0、二十碳五烯酸和二十二碳六烯酸浓度显著高于第一组母亲。与第一组新生儿相比，第二组新生儿的总饱和脂肪酸和多不饱和脂肪酸浓度显著较低，但总n-3多不饱和脂肪酸和二十二碳六烯酸浓度显著较高（p<0.05）。孕妇血清和脐带血清中的n-6:n-3比值分别约为10:1和1.5:1。
分娩巨大儿的孕期体重过度增加的女性，其新生儿脐带血清中的总饱和脂肪酸浓度往往较高，但二十二碳六烯酸浓度较低。孕妇血清和脐带血清中的脂肪酸浓度与孕妇的饮食模式无关。
