Department of Histology and Embryology, College of Basic Medical Sciences, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China.
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Science, Beijing, China.
J Med Virol. 2020 Jul;92(7):707-709. doi: 10.1002/jmv.25824. Epub 2020 Apr 10.
In a recent review, we have suggested a neuroinvasive potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its possible role in the causation of acute respiratory failure of coronavirus disease 2019 (COVID-19) patients (J Med Viol doi: 10.1002/jmv.25728), based upon the clinical and experimental data available on the past SARS-CoV-1 and the recent SARS-CoV-2 pandemic. In this article, we provide new evidence recently reported regarding the neurotropic potential of SARS-CoV-2 and respond to several comments on our previously published article. In addition, we also discuss the peculiar manifestations of respiratory failure in COVID-19 patients and the possible involvement of nervous system.
在最近的一篇综述中,我们根据过去 SARS-CoV-1 和最近 SARS-CoV-2 大流行期间现有的临床和实验数据,提出了严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)具有神经侵袭性的可能性及其在导致 2019 年冠状病毒病(COVID-19)患者急性呼吸衰竭中的可能作用(J Med Viol doi: 10.1002/jmv.25728)。在本文中,我们提供了最近关于 SARS-CoV-2 神经嗜性潜力的新证据,并对我们之前发表的文章的几个评论做出了回应。此外,我们还讨论了 COVID-19 患者呼吸衰竭的特殊表现以及神经系统可能的参与。