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新型冠状病毒肺炎(COVID-19)与糖尿病:关联性加剧发病和死亡风险因素。

COVID-19 and diabetes: Association intensify risk factors for morbidity and mortality.

机构信息

Chitkara College of Pharmacy, Chitkara University, Punjab, India; Government Pharmacy College, Nagrota Bagwan, Kangra, Himachal Pradesh, India.

Chitkara College of Pharmacy, Chitkara University, Punjab, India.

出版信息

Biomed Pharmacother. 2022 Jul;151:113089. doi: 10.1016/j.biopha.2022.113089. Epub 2022 May 8.

Abstract

Diabetes is a condition that affects a large percentage of the population and it is the leading cause of a wide range of costly complications. Diabetes is linked to a multi-fold increase in mortality and when compared to non-diabetics, the intensity and prevalence of COVID-19 ailment among diabetic individuals are more. Since its discovery in Wuhan, COVID-19 has grown rapidly and shown a wide range of severity. Temperature, lymphopenia, non-productive cough, dyspnoea, and tiredness are recognized as the characteristic of individuals infected with COVID-19 disease. In COVID-19 patients, diabetes and other related comorbidities are substantial predictors of disease and mortality. According to a recent study, SARS-CoV-2 (the virus responsible for covid-19 disease) may also lead to direct pancreatic harm, which could aggravate hyperglycemia and potentially cause the establishment of diabetes in formerly non-diabetic individuals. This bidirectional association of COVID-19 and diabetes load the burden on health care professionals throughout the world. It is recommended that gliptin medications be taken moderately, blood glucose levels must be kept under control, ACE inhibitors should be used in moderation, decrease the number of avoidable hospitalizations, nutritional considerations, and some other prevention measures, such as immunization, are highly recommended. SARS-CoV-2 may cause pleiotropic changes in glucose homeostasis, which could exacerbate the pathophysiology of pre-existing diabetes or result in new disease processes.

摘要

糖尿病是一种影响很大比例人群的疾病,也是多种昂贵并发症的主要原因。糖尿病与死亡率呈多倍增加相关,与非糖尿病患者相比,糖尿病患者 COVID-19 疾病的强度和患病率更高。自武汉发现以来,COVID-19 迅速传播,表现出广泛的严重程度。发热、淋巴细胞减少、无痰干咳、呼吸困难和乏力被认为是 COVID-19 疾病感染者的特征。在 COVID-19 患者中,糖尿病和其他相关合并症是疾病和死亡率的重要预测因素。根据最近的一项研究,SARS-CoV-2(导致 COVID-19 疾病的病毒)也可能导致直接的胰腺损伤,这可能会加重高血糖,并有可能导致以前非糖尿病患者患上糖尿病。COVID-19 和糖尿病之间的这种双向关联给全世界的医疗保健专业人员带来了负担。建议适度使用格列汀类药物,控制血糖水平,适度使用 ACE 抑制剂,减少不必要的住院治疗,考虑营养问题,以及其他一些预防措施,如免疫接种,这些都是高度推荐的。SARS-CoV-2 可能会导致葡萄糖内稳态的多效变化,这可能会加重原有糖尿病的病理生理过程或导致新的疾病过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31dc/9080053/f3c8d585904e/ga1_lrg.jpg

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