Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, 14194, Iran.
Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Dr. Qarib St, Keshavarz Blvd, Tehran, 14194, Iran.
Rev Neurosci. 2020 May 26;31(4):453-456. doi: 10.1515/revneuro-2020-0026.
Coronaviruses disease (COVID-19) has caused major outbreaks. A novel variant, SARS-CoV-2, is responsible for COVID-19 pandemic. Clinical presentations and pathological mechanisms of COVID-19 are broad. The respiratory aspect of the disease has been extensively researched. Emerging studies point out the possibility of the central nervous system (CNS) involvement by COVID-19. Here, we discuss the current evidence for CNS involvement in COVID-19 and highlight that the high pathogenicity of SARS-CoV-2 might be due to its neuroinvasive potential.
冠状病毒病（COVID-19）已引发重大疫情。一种新型变异株，即严重急性呼吸综合征冠状病毒 2（SARS-CoV-2），引发了 COVID-19 大流行。COVID-19 的临床表现和病理机制广泛存在。该病的呼吸道方面已得到广泛研究。新出现的研究指出 COVID-19 可能涉及中枢神经系统（CNS）。在此，我们讨论 COVID-19 中 CNS 受累的现有证据，并强调 SARS-CoV-2 的高致病性可能与其神经侵袭潜能有关。
