C-反应蛋白（CRP）或高敏 C-反应蛋白在预测妊娠期糖尿病中的作用：系统评价。
Role of C-reactive Protein(CRP) or high-sensitivity CRP in predicting gestational diabetes Mellitus:Systematic review.
机构信息
Department of Midwifery, School of Nursing and Midwifery, Jiroft University of Medical Sciences, Jiroft, Iran.
Student Research Committee, Nursing and Midwifery Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Diabetes Metab Syndr. 2020 May-Jun;14(3):229-236. doi: 10.1016/j.dsx.2020.02.004. Epub 2020 Mar 16.
BACKGROUND AND AIMS
Gestational Diabetes Mellitus (GDM) is the most common disorder during pregnancy in 8-18% of pregnancies. Due to maternal and neonatal morbidity and mortality, early diagnosis and appropriate treatment have always been of interest to researchers. One of the recent cases for early diagnosis of GDM is the size of the C-reactive protein (CRP). The purpose of this review study was to investigate the role of CRP or its high sensitivity type in predicting GDM.
METHODS
Systematic searching of MEDLINE, ISI Web of Science, PubMed, Scopus, Google Scholar, and ProQuest databases between 2009 and 2019 using keywords 'Gestational Diabetes Mellitus','Screening', 'C-reactive protein',' High sensitivity CRP'was performed. The quality of articles was also assessed using the STROBE checklist.
RESULTS
After a thorough search of the mentioned databases, 31 articles with the desired quality were finally selected. Most of studies showed significant relationship between CRP or high-sensitivity CRP(hs-CRP) level with GDMbutthe relationship was not significant in fewstudies.
CONCLUSIONS
Blood levels of CRP or hs-CRP could be used as a potential indicator for GDM, but more studies are needed.
背景与目的
妊娠糖尿病（GDM）是妊娠中最常见的疾病之一，约占 8-18%的妊娠。由于母婴发病率和死亡率较高，早期诊断和适当的治疗一直是研究人员关注的焦点。最近，C 反应蛋白（CRP）的大小被认为是 GDM 的早期诊断方法之一。本综述研究的目的是探讨 CRP 或其高敏型在预测 GDM 中的作用。
方法
系统检索 2009 年至 2019 年 MEDLINE、ISI Web of Science、PubMed、Scopus、Google Scholar 和 ProQuest 数据库，使用关键词“Gestational Diabetes Mellitus”、“Screening”、“C-reactive protein”、“High sensitivity CRP”进行检索。还使用 STROBE 清单评估文章的质量。
结果
在对上述数据库进行彻底搜索后，最终选择了 31 篇符合要求的高质量文章。大多数研究表明 CRP 或高敏型 CRP（hs-CRP）水平与 GDM 之间存在显著关系，但也有少数研究显示这种关系不显著。
结论
CRP 或 hs-CRP 的血液水平可作为 GDM 的潜在指标，但需要更多的研究。
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