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A Call for Randomized Controlled Trials to Test the Efficacy of Chloroquine and Hydroxychloroquine as Therapeutics against Novel Coronavirus Disease (COVID-19).呼吁开展随机对照试验以测试氯喹和羟氯喹作为治疗新型冠状病毒病（COVID-19）药物的疗效
Am J Trop Med Hyg. 2020 May;102(5):932-933. doi: 10.4269/ajtmh.20-0230.
2
Why Your Patients' Believing Hydroxychloroquine and Chloroquine Are 90% Effective for COVID-19 Is 100% Dangerous.为何您的患者认为羟氯喹和氯喹对新冠病毒病有90%的疗效是极其危险的。
J Clin Pharmacol. 2020 Aug;60(8):949-953. doi: 10.1002/jcph.1687. Epub 2020 Jul 1.
3
Safety considerations for chloroquine and hydroxychloroquine in the treatment of COVID-19.氯喹和羟氯喹用于治疗新型冠状病毒肺炎的安全性考量
Clin Microbiol Infect. 2020 Sep;26(9):1276-1277. doi: 10.1016/j.cmi.2020.05.006. Epub 2020 May 16.
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Ventricular arrhythmia risk due to chloroquine / hydroxychloroquine treatment for COVID-19: Should it be given.用于治疗新冠肺炎的氯喹/羟氯喹引发室性心律失常的风险：是否应该使用该药？
Indian Heart J. 2020 Mar-Apr;72(2):131-132. doi: 10.1016/j.ihj.2020.04.006. Epub 2020 Apr 27.
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Use of Chloroquine and Hydroxychloroquine in COVID-19 and Cardiovascular Implications: Understanding Safety Discrepancies to Improve Interpretation and Design of Clinical Trials.氯喹和羟氯喹在2019冠状病毒病中的应用及其心血管影响：理解安全性差异以改进临床试验的解读与设计
Circ Arrhythm Electrophysiol. 2020 Jun;13(6):e008688. doi: 10.1161/CIRCEP.120.008688. Epub 2020 May 21.
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COVID-19 and Antimalarial Drugs: Harms Outweigh Benefits.新型冠状病毒肺炎与抗疟药物：弊大于利
Am J Crit Care. 2020 Nov 1;29(6):489-492. doi: 10.4037/ajcc2020694.
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Regulators split on antimalarials for COVID-19.监管机构在用于治疗新冠肺炎的抗疟疾药物问题上存在分歧。
Lancet. 2020 Apr 11;395(10231):1179. doi: 10.1016/S0140-6736(20)30817-5.
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Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know.在 COVID-19 大流行期间使用羟氯喹和氯喹：每个临床医生都应该知道的事。
Ann Intern Med. 2020 Jun 2;172(11):754-755. doi: 10.7326/M20-1334. Epub 2020 Mar 31.
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Chloroquine and hydroxychloroquine in covid-19.氯喹和羟氯喹在2019冠状病毒病中的应用
BMJ. 2020 Apr 8;369:m1432. doi: 10.1136/bmj.m1432.
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Brief Review of Chloroquine and Hydroxychloroquine Toxicity and Management.氯喹和羟氯喹毒性及处理的简要综述。
West J Emerg Med. 2020 Jun 3;21(4):760-763. doi: 10.5811/westjem.2020.5.47810.

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Efficacy and safety of hydroxychloroquine for treatment of mild SARS-CoV-2 infection and prevention of COVID-19 severity in pregnant and postpartum women: A randomized, double-blind, placebo-controlled trial.羟氯喹治疗轻症 SARS-CoV-2 感染和预防 COVID-19 严重程度的疗效和安全性：一项随机、双盲、安慰剂对照试验。
Acta Obstet Gynecol Scand. 2024 Mar;103(3):602-610. doi: 10.1111/aogs.14745. Epub 2023 Dec 14.
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Safety of Short-Term Treatments with Oral Chloroquine and Hydroxychloroquine in Patients with and without COVID-19: A Systematic Review.新型冠状病毒肺炎患者与非新型冠状病毒肺炎患者短期口服氯喹和羟氯喹治疗的安全性：一项系统评价
Pharmaceuticals (Basel). 2022 May 21;15(5):634. doi: 10.3390/ph15050634.
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Role of Multifunctional Cytoskeletal Filaments in Infections: Therapeutic Opportunities for COVID-19 in a Nutshell.多功能细胞骨架丝在感染中的作用：COVID-19 的治疗机会简述。
Cells. 2021 Jul 19;10(7):1818. doi: 10.3390/cells10071818.
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Roles of existing drug and drug targets for COVID-19 management.现有药物及药物靶点在新冠肺炎治疗中的作用。
Metabol Open. 2021 Sep;11:100103. doi: 10.1016/j.metop.2021.100103. Epub 2021 Jun 29.
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The journey of antimalarial drugs against SARS-CoV-2: Review article.抗疟药物对抗严重急性呼吸综合征冠状病毒2的历程：综述文章。
Inform Med Unlocked. 2021;24:100604. doi: 10.1016/j.imu.2021.100604. Epub 2021 May 19.
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Efficacy and safety of chloroquine and hydroxychloroquine for treatment of COVID-19 patients-a systematic review and meta-analysis of randomized controlled trials.氯喹和羟氯喹治疗新型冠状病毒肺炎患者的疗效与安全性——一项随机对照试验的系统评价与荟萃分析
Am J Cardiovasc Dis. 2021 Feb 15;11(1):93-107. eCollection 2021.
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COVID-19 prevention and treatment: A critical analysis of chloroquine and hydroxychloroquine clinical pharmacology.新型冠状病毒肺炎防治：氯喹和羟氯喹临床药理学的批判性分析。
PLoS Med. 2020 Sep 3;17(9):e1003252. doi: 10.1371/journal.pmed.1003252. eCollection 2020 Sep.
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Mesenchymal Stem Cell Derived Exosomes: a Nano Platform for Therapeutics and Drug Delivery in Combating COVID-19.间充质干细胞衍生的外泌体：用于治疗 COVID-19 的治疗学和药物递送的纳米平台。
Stem Cell Rev Rep. 2021 Feb;17(1):33-43. doi: 10.1007/s12015-020-10002-z.
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Drug targets for COVID-19 therapeutics: Ongoing global efforts.抗新冠病毒药物靶点：全球努力持续进行中。
J Biosci. 2020;45(1). doi: 10.1007/s12038-020-00067-w.
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How COVID-19 affects patients receiving anticytokine and JAK inhibitors in rheumatology and dermatology.新型冠状病毒肺炎如何影响在风湿病学和皮肤病学中接受抗细胞因子和JAK抑制剂治疗的患者。
Immunotherapy. 2020 Oct;12(15):1115-1119. doi: 10.2217/imt-2020-0153. Epub 2020 Jul 9.

本文引用的文献

1
Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2 and SARS-CoV .食品和药物管理局批准的药物对 SARS-CoV-2 和 SARS-CoV 的广谱抗病毒活性。
J Virol. 2020 Oct 14;94(21). doi: 10.1128/JVI.01218-20.
2
Race to find COVID-19 treatments accelerates.寻找新冠病毒治疗方法的竞赛加速。
Science. 2020 Mar 27;367(6485):1412-1413. doi: 10.1126/science.367.6485.1412.
3
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.羟氯喹和阿奇霉素治疗 COVID-19：一项开放标签非随机临床试验的结果。
Int J Antimicrob Agents. 2020 Jul;56(1):105949. doi: 10.1016/j.ijantimicag.2020.105949. Epub 2020 Mar 20.
4
In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).羟氯喹治疗严重急性呼吸综合征冠状病毒 2 （SARS-CoV-2）的体外抗病毒活性和优化剂量设计预测。
Clin Infect Dis. 2020 Jul 28;71(15):732-739. doi: 10.1093/cid/ciaa237.
5
SARS-CoV-2: a potential novel etiology of fulminant myocarditis.严重急性呼吸综合征冠状病毒2：暴发性心肌炎的一种潜在新病因。
Herz. 2020 May;45(3):230-232. doi: 10.1007/s00059-020-04909-z.
6
Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.突破：磷酸氯喹在临床研究中显示出对 COVID-19 相关肺炎的明显疗效。
Biosci Trends. 2020 Mar 16;14(1):72-73. doi: 10.5582/bst.2020.01047. Epub 2020 Feb 19.
7
Chloroquine inhibited Ebola virus replication in vitro but failed to protect against infection and disease in the in vivo guinea pig model.氯喹在体外可抑制埃博拉病毒复制，但在体内豚鼠模型中未能预防感染和疾病。
J Gen Virol. 2015 Dec;96(12):3484-3492. doi: 10.1099/jgv.0.000309.
8
Chloroquine for influenza prevention: a randomised, double-blind, placebo controlled trial.氯喹预防流感：一项随机、双盲、安慰剂对照试验。
Lancet Infect Dis. 2011 Sep;11(9):677-83. doi: 10.1016/S1473-3099(11)70065-2. Epub 2011 May 5.
9
A randomized controlled trial of chloroquine for the treatment of dengue in Vietnamese adults.一项在越南成年人中氯喹治疗登革热的随机对照试验。
PLoS Negl Trop Dis. 2010 Aug 10;4(8):e785. doi: 10.1371/journal.pntd.0000785.
10
On chikungunya acute infection and chloroquine treatment.关于基孔肯雅热急性感染与氯喹治疗
Vector Borne Zoonotic Dis. 2008 Dec;8(6):837-9. doi: 10.1089/vbz.2008.0049.

A Call for Randomized Controlled Trials to Test the Efficacy of Chloroquine and Hydroxychloroquine as Therapeutics against Novel Coronavirus Disease (COVID-19).

作者信息

Keshtkar-Jahromi Maryam, Bavari Sina

机构信息

Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Edge BioInnovation Consulting, Frederick, Maryland.

出版信息

Am J Trop Med Hyg. 2020 May;102(5):932-933. doi: 10.4269/ajtmh.20-0230.

DOI:10.4269/ajtmh.20-0230
PMID:32247318
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7204586/
Abstract
摘要