关于配子不平衡的度量。
On measures of gametic disequilibrium.
作者信息
Lewontin R C
机构信息
Museum of Comparative Zoology, Harvard University, Cambridge, Massachusetts 02138.
出版信息
Genetics. 1988 Nov;120(3):849-52. doi: 10.1093/genetics/120.3.849.
Abstract
Various measures have been proposed for characterizing the statistical association that arises between alleles at different loci. Hedrick has compared these measures with the standardized measure D' proposed by Lewontin on the grounds that this latter measure is independent of allele frequency. Although D' has the same range for all allelic frequencies, in fact, D' is not "independent" of allele frequency, and no measure with that general property is possible for the multilocus association problem. The insolubility of this problem arises from the ill-defined nature of general "association."
摘要
人们已经提出了各种方法来描述不同位点等位基因之间产生的统计关联。赫德里克将这些方法与莱温廷提出的标准化度量D'进行了比较，理由是后一种度量与等位基因频率无关。尽管D'对于所有等位基因频率都有相同的范围，但实际上，D'并非与等位基因频率“无关”，而且对于多位点关联问题，不存在具有那种一般性质的度量。这个问题无法解决是由于一般“关联”的性质不明确。
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本文引用的文献
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The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models.选择与连锁的相互作用。I. 一般考量；杂种优势模型。
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