Fimmel Elena, Starman Martin, Strüngmann Lutz
Institute of Mathematical Biology, Faculty for Computer Sciences, Mannheim University of Applied Sciences, 68163, Mannheim, Germany.
Bull Math Biol. 2020 Apr 4;82(4):48. doi: 10.1007/s11538-020-00724-z.
The origin of the modern genetic code and the mechanisms that have contributed to its present form raise many questions. The main goal of this work is to test two hypotheses concerning the development of the genetic code for their compatibility and complementarity and see if they could benefit from each other. On the one hand, Gonzalez, Giannerini and Rosa developed a theory, based on four-based codons, which they called tesserae. This theory can explain the degeneracy of the modern vertebrate mitochondrial code. On the other hand, in the 1990s, so-called circular codes were discovered in nature, which seem to ensure the maintenance of a correct reading-frame during the translation process. It turns out that the two concepts not only do not contradict each other, but on the contrary complement and enrichen each other.
现代遗传密码的起源以及促成其当前形式的机制引发了许多问题。这项工作的主要目标是检验关于遗传密码发展的两种假说，看它们是否兼容互补，以及能否相互借鉴。一方面，冈萨雷斯、贾内里尼和罗萨基于四碱基密码子（他们称之为镶嵌体）提出了一种理论。该理论可以解释现代脊椎动物线粒体密码的简并性。另一方面，在20世纪90年代，自然界中发现了所谓的环形密码，它们似乎能确保在翻译过程中维持正确的阅读框。结果表明，这两个概念不仅不相互矛盾，反而相互补充和丰富。
