Morimoto Akiko, Ueda Yutaka, Egawa-Takata Tomomi, Yagi Asami, Terai Yoshito, Ohmichi Masahide, Ichimura Tomoyuki, Sumi Toshiyuki, Murata Hiromi, Kanzaki Hideharu, Nakai Hidekatsu, Mandai Masaki, Yoshino Kiyoshi, Fujita Masami, Kimura Tadashi, Saito Junko, Sobue Tomotaka, Nishikawa Nobumichi, Sekine Masayuki, Enomoto Takayuki, Horikoshi Yorihiko, Takagi Tetsu
The Obstetrical Gynecological Society of Osaka, 4-4-3 Kawaramachi, Chuo-ku, Osaka, 541-0048, Japan.
Int J Clin Oncol. 2015 Jun;20(3):549-55. doi: 10.1007/s10147-014-0723-1. Epub 2014 Jul 9.
Administration of the human papillomavirus (HPV) vaccine decreased dramatically in Japan after extensive news of adverse vaccine events and suspension of the governmental recommendation for the vaccine. In this study, we investigated the knowledge and acceptance of vaccinated adolescents concerning cervical cancer, cancer screening and the HPV vaccine. Furthermore, we analyzed whether and by how much the news affected acceptance of the vaccination.
This study was conducted as a part of Osaka Clinical resEArch of HPV vacciNe (OCEAN) study. A questionnaire was distributed to 2,777 study registrants.
The response rate was 38%. The recognition rate of the news of the vaccine's adverse events was 80%; it was 68% for awareness of the government's announcement of the suspension of its recommendation for the vaccine. Among those who had a chance to hear or see the negative news during their vaccination period, 46 (60%) continued vaccination while knowing of the news, 22 (29%) discontinued vaccination, and 9 (11%) continued vaccination without an awareness of the news. Reports of the vaccine's adverse events were the main reason for not continuing the vaccination series. Those who consulted doctors after hearing the adverse news were significantly more likely to continue their vaccinations than those who did not.
Our results should help in understanding the need for a strong promotion of vaccine usage and cancer screening after future retraction of the recommendation suspension. This may apply to other countries with an unsatisfactory rate of HPV vaccination due to fears of adverse vaccine events.
在大量关于疫苗不良事件的新闻报道以及政府暂停对该疫苗的推荐后，日本的人乳头瘤病毒（HPV）疫苗接种率大幅下降。在本研究中，我们调查了接种疫苗的青少年对宫颈癌、癌症筛查及HPV疫苗的了解和接受情况。此外，我们分析了这些新闻是否以及在多大程度上影响了对疫苗接种的接受度。
本研究作为大阪HPV疫苗临床研究（OCEAN）的一部分开展。向2777名研究登记参与者发放了问卷。
回复率为38%。疫苗不良事件新闻的知晓率为80%；政府宣布暂停推荐该疫苗的知晓率为68%。在接种疫苗期间有机会听到或看到负面新闻的人群中，46人（60%）在知晓新闻的情况下继续接种，22人（29%）停止接种，9人（11%）在不知晓新闻的情况下继续接种。疫苗不良事件的报道是未继续完成疫苗接种系列的主要原因。听到不良新闻后咨询医生的人比未咨询的人更有可能继续接种。
我们的研究结果应有助于理解在未来撤销推荐暂停后大力推广疫苗使用和癌症筛查的必要性。这可能适用于因担心疫苗不良事件而HPV疫苗接种率不理想的其他国家。
