Department of Ophthalmology, Odense University Hospital, Odense, Denmark.
Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Acta Ophthalmol. 2020 Sep;98(6):573-578. doi: 10.1111/aos.14415. Epub 2020 Apr 5.
The Danish Excellence Centre in Ophthalmic Epidemiology (DECODE-EYE) is a national research collaboration formed in order to study the real-life interaction between ocular and systemic disease based on the entire Danish population. Here, we aim to describe the study design and the methodology, which will be used.
We will extract data from various healthcare registers and databases including the Danish Civil Registration System (unique personal identifier), the Danish National Patient Register (inpatient and outpatient visits), the Danish National Prescription Registry (redeemed prescription drugs), the National Health Service Register (data on health services in primary health care), the Danish Register of Cause of Death (data on cause of death), Statistics Denmark (demographic and socioeconomic data), the Danish Registry of Diabetic Retinopathy (level of diabetic retinopathy (DR) in diabetes patients) and the database of the Danish Association of the Blind (date and cause of blindness). Relevant registers will be linked by the unique personal identifier, and associations will be examined cross-sectional and/or longitudinally, in principle in 1:5 age- and gender-matched case-control cohort studies.
Denmark has a strong tradition in register-based healthcare research, given a high number of validated national registers and databases. DECODE-EYE will provide Danish, large-scale data on associations between ocular and systemic disease. With a target population of 5.8 million individuals, twelve separate studies (Protocols A-L) have initially been designed to be studied in the upcoming years. These will provide novel data on interactions between systemic disease and relevant ophthalmological end-points like blindness, DR, glaucoma, corneal disease, retinal vascular disease, cataract and intravitreal angiostatic treatment.
丹麦眼科流行病学卓越中心（DECODE-EYE）是一个国家研究合作组织，旨在基于丹麦全体人口研究眼部疾病和全身疾病之间的实际相互作用。在此，我们旨在描述将使用的研究设计和方法。
我们将从各种医疗保健登记处和数据库中提取数据，包括丹麦民事登记系统（唯一身份识别码）、丹麦国家患者登记处（住院和门诊就诊）、丹麦国家处方登记处（已使用处方药物）、国家卫生服务登记处（初级卫生保健服务数据）、丹麦死因登记处（死因数据）、丹麦统计局（人口和社会经济数据）、丹麦糖尿病视网膜病变登记处（糖尿病患者的糖尿病视网膜病变（DR）水平）和丹麦盲人协会数据库（失明日期和原因）。相关登记处将通过唯一身份识别码进行链接，关联将在原则上以 1:5 的年龄和性别匹配病例对照队列研究进行横断面和/或纵向研究。
鉴于丹麦有大量经过验证的国家登记处和数据库，因此在基于登记的医疗保健研究方面具有很强的传统。DECODE-EYE 将提供丹麦大规模的眼部疾病和全身疾病之间关联的数据。目标人群为 580 万人，最初已设计了 12 项单独的研究（方案 A-L），计划在未来几年内进行研究。这些研究将提供关于全身疾病与相关眼科终点（如失明、DR、青光眼、角膜疾病、视网膜血管疾病、白内障和玻璃体内血管生成抑制治疗）之间相互作用的新数据。
