Tian Ting, Wang Yuanyuan, Xie Wei, Zhang Jingxian, Zhu Qianrang, Peng Xianzhen, Zhou Yonglin, Dai Yue
Institute of Food Safety and Assessment, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, 210009, People's Republic of China.
Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, 210009, People's Republic of China.
Diabetes Metab Syndr Obes. 2021 Jul 28;14:3447-3460. doi: 10.2147/DMSO.S323917. eCollection 2021.
The relationship between serum uric acid (SUA) and Chinese characteristic 10-year atherosclerotic cardiovascular disease (ASCVD) risk score has not been well evaluated in Chinese populations. Aims of this cross-sectional study were to describe the correlation between SUA level and clustering of prevalent cardiovascular risk factors (CRFs) including overweight, central obesity, hypertension, diabetes and dyslipidemia, as well as the Chinese 10-year ASCVD risk score in adults from Jiangsu Province located in Eastern China.
A total of 7700 adults from 12 cities in Jiangsu Province were selected through multi-stage stratified cluster random sampling method in 2015. Face-to-face interviews, physical examinations and laboratory examinations were carried out to collect the information of the participants. Multivariate logistic analysis was used to analyze the relationship between SUA quartiles and various CVD risk factors. The nonlinear analysis was conducted to evaluate the relationship between SUA levels and the China-PAR 10-year ASCVD risk scores.
The prevalence of hyperuricemia was 13.3% in all of the participants. By adjusting potential confounders, significant correlations were found between the SUA level and the overweight, central obesity, hypertension and dyslipidemia in both males and females. The clustering of CRFs was different across SUA quantiles ( =607.685, <0.001). After Gamma trend test ( < 0.001) and ordered logistic regression analysis, it was found out that with the increase of SUA quantiles, prevalent CRFs gradually gathered in both males and females. Furthermore, sex-specific difference was identified between SUA and 10-year ASCVD risk scores.
The accumulation of CRFs increased with elevated SUA levels, whereas it was different between genders in the relationship between SUA and 10-year ASCVD risk scores. Tailored strategies should be taken when it came to males and females in managing SUA.
在中国人群中，血清尿酸（SUA）与中国特色的10年动脉粥样硬化性心血管疾病（ASCVD）风险评分之间的关系尚未得到充分评估。这项横断面研究的目的是描述中国东部江苏省成年人中SUA水平与包括超重、中心性肥胖、高血压、糖尿病和血脂异常在内的心血管危险因素聚集情况以及中国10年ASCVD风险评分之间的相关性。
2015年通过多阶段分层整群随机抽样方法，从江苏省12个城市选取了7700名成年人。进行面对面访谈、体格检查和实验室检查以收集参与者的信息。采用多因素逻辑分析来分析SUA四分位数与各种心血管疾病危险因素之间的关系。进行非线性分析以评估SUA水平与中国PAR 10年ASCVD风险评分之间的关系。
所有参与者中高尿酸血症的患病率为13.3%。通过调整潜在混杂因素，发现男性和女性的SUA水平与超重、中心性肥胖、高血压和血脂异常之间均存在显著相关性。心血管危险因素的聚集在SUA四分位数之间存在差异（χ² = 607.685，P < 0.001）。经过Gamma趋势检验（P < 0.001）和有序逻辑回归分析，发现随着SUA四分位数的增加，男性和女性中普遍存在的心血管危险因素逐渐聚集。此外，在SUA与10年ASCVD风险评分之间发现了性别特异性差异。
心血管危险因素的聚集随着SUA水平的升高而增加，而在SUA与10年ASCVD风险评分的关系中存在性别差异。在管理SUA时，针对男性和女性应采取不同策略。
