Jain Dharmendra, Rao Sunil Kumar, Kumar Dhilip, Kumar Ashok, Sihag Bhupendra Kumar
Department of Cardiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Indian Heart J. 2019 Nov-Dec;71(6):492-495. doi: 10.1016/j.ihj.2020.01.005. Epub 2020 Feb 4.
Severe acute malnutrition (SAM) may affect cardiac structure and function. Cardiac changes in sick children with SAM have received little attention in the literature. Children aged 6-60 months with SAM were cases, and age and sex matched children were controls. Cardiac biomarker levels were measured by the quantitative the Enzyme- linked immunosorbent assay (ELISA) method, and echocardiography was used to assess cardiac changes in all children. The study included 76 children in each group. Children with SAM had less left ventricular mass and increased myocardial performance index as compared with controls (p < 0.0001). Cardiac biomarker levels were increased in children with SAM (p < 0.0001). Cardiac changes and biomarker levels were comparable in children with edema and children without edema except creatine kinase-MB (p = 0.01).
重度急性营养不良（SAM）可能会影响心脏结构和功能。患有SAM的患病儿童的心脏变化在文献中很少受到关注。年龄在6至60个月的患有SAM的儿童为病例组，年龄和性别匹配的儿童为对照组。通过定量酶联免疫吸附测定（ELISA）法测量心脏生物标志物水平，并使用超声心动图评估所有儿童的心脏变化。每组包括76名儿童。与对照组相比，患有SAM的儿童左心室质量较小，心肌性能指数增加（p < 0.0001）。患有SAM的儿童心脏生物标志物水平升高（p < 0.0001）。除肌酸激酶-MB外（p = 0.01），有水肿和无水肿儿童的心脏变化及生物标志物水平具有可比性。
