B 细胞在多发性硬化症免疫发病机制中的作用。
The role of B cells in the immunopathogenesis of multiple sclerosis.
机构信息
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Immunology. 2020 Aug;160(4):325-335. doi: 10.1111/imm.13198. Epub 2020 May 10.
Abstract
There is ongoing debate on how B cells contribute to the pathogenesis of multiple sclerosis (MS). The success of B-cell targeting therapies in MS highlighted the role of B cells, particularly the antibody-independent functions of these cells such as antigen presentation to T cells and modulation of the function of T cells and myeloid cells by secreting pathogenic and/or protective cytokines in the central nervous system. Here, we discuss the role of different antibody-dependent and antibody-independent functions of B cells in MS disease activity and progression proposing new therapeutic strategies for the optimization of B-cell targeting treatments.
摘要
目前，关于 B 细胞如何导致多发性硬化症（MS）的发病机制仍存在争议。B 细胞靶向治疗在 MS 中的成功凸显了 B 细胞的作用，特别是这些细胞的抗体非依赖性功能，例如将抗原呈递给 T 细胞，以及通过在中枢神经系统中分泌致病性和/或保护性细胞因子来调节 T 细胞和髓样细胞的功能。在这里，我们讨论了 B 细胞在 MS 疾病活动和进展中的不同抗体依赖性和抗体非依赖性功能的作用，并提出了优化 B 细胞靶向治疗的新治疗策略。
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2
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