Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Immunology. 2020 Aug;160(4):325-335. doi: 10.1111/imm.13198. Epub 2020 May 10.
There is ongoing debate on how B cells contribute to the pathogenesis of multiple sclerosis (MS). The success of B-cell targeting therapies in MS highlighted the role of B cells, particularly the antibody-independent functions of these cells such as antigen presentation to T cells and modulation of the function of T cells and myeloid cells by secreting pathogenic and/or protective cytokines in the central nervous system. Here, we discuss the role of different antibody-dependent and antibody-independent functions of B cells in MS disease activity and progression proposing new therapeutic strategies for the optimization of B-cell targeting treatments.
目前,关于 B 细胞如何导致多发性硬化症(MS)的发病机制仍存在争议。B 细胞靶向治疗在 MS 中的成功凸显了 B 细胞的作用,特别是这些细胞的抗体非依赖性功能,例如将抗原呈递给 T 细胞,以及通过在中枢神经系统中分泌致病性和/或保护性细胞因子来调节 T 细胞和髓样细胞的功能。在这里,我们讨论了 B 细胞在 MS 疾病活动和进展中的不同抗体依赖性和抗体非依赖性功能的作用,并提出了优化 B 细胞靶向治疗的新治疗策略。