Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Cold Spring Harb Perspect Med. 2019 Apr 1;9(4):a029108. doi: 10.1101/cshperspect.a029108.
Increasing evidence has suggested that both antibody-dependent and antibody-independent functions of B cells are involved in multiple sclerosis (MS). The contrasting results of distinct B-cell targeting therapies in MS patients underscores the importance of elucidating these multiple B-cell functions. In this review, we discuss the generation of autoreactive B cells, migration of B cells into the central nervous system (CNS), and how different functions of B cells may contribute to MS disease activity and potentially mitigation in both the periphery and CNS compartments. In addition, we propose several future therapeutic strategies that may better target/shape B-cell responses for long-term treatment of MS.
越来越多的证据表明，B 细胞的抗体依赖和非依赖功能都参与了多发性硬化症（MS）。不同的 B 细胞靶向治疗在 MS 患者中的对比结果突出了阐明这些多种 B 细胞功能的重要性。在这篇综述中，我们讨论了自身反应性 B 细胞的产生、B 细胞向中枢神经系统（CNS）的迁移，以及 B 细胞的不同功能如何有助于 MS 疾病的活动，以及在周围和中枢神经系统中可能得到缓解。此外，我们提出了几种未来的治疗策略，这些策略可能更好地针对/塑造 B 细胞的反应，从而实现 MS 的长期治疗。
