Department of Laboratory Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Int J Lab Hematol. 2020 Aug;42(4):387-393. doi: 10.1111/ijlh.13194. Epub 2020 Apr 6.
The hypercoagulability of blood is related to the development and metastasis of cancer. High levels of D-dimer have been reported to be associated with the metastasis and poor prognoses of cancer. Here, we investigated the performance of biomarkers-TAT, PIC, TM, and tPAI·C by new method-for monitoring cancer patients with metastasis.
A total of 197 cancer patients were enrolled. TM, TAT, PIC, and tPAI·C were detected by the chemiluminescence immunoassay.
Results showed that the levels of TAT and PIC were higher in the metastasis group than those in the nonmetastasis group (P < .01). In the nonmetastasis group, there were 16 patients with elevated levels of D-dimer. But, TAT and PIC in these 16 patients were all at normal level (<0.55 mg/L FEU). After dilution, D-dimer was also decreased to normal levels in these 16 patients. The ROC was used to show the performance of D-dimer, TAT, and PIC on indicating cancer with metastasis. The AUC of PIC was higher than that of D-dimer (0.825 vs. 0.770). The specificity and PPV of TAT and PIC were higher than those of D-dimer. Serial test of TAT, PIC, and D-dimer improved the specificity and positive predictive value to 90.91% [80.61%, 96.25%] and 89.29% [77.45%, 95.57%], respectively.
Combining TAT and PIC with D-dimer could be useful surveillance biomarkers for cancer with metastasis.
血液的高凝状态与癌症的发展和转移有关。已有研究报道，D-二聚体水平升高与癌症的转移和不良预后相关。在这里，我们研究了新方法检测的生物标志物-TAT、PIC、TM 和 tPAI·C 在监测有转移的癌症患者中的性能。
共纳入 197 例癌症患者。采用化学发光免疫分析法检测 TM、TAT、PIC 和 tPAI·C。
结果显示，转移组 TAT 和 PIC 水平高于非转移组（P<0.01）。在非转移组中，有 16 例患者 D-二聚体水平升高。但这 16 例患者的 TAT 和 PIC 均处于正常水平（<0.55mg/L FEU）。经稀释后，这 16 例患者的 D-二聚体也降至正常水平。ROC 用于显示 D-二聚体、TAT 和 PIC 对指示癌症转移的性能。PIC 的 AUC 高于 D-二聚体（0.825 比 0.770）。TAT 和 PIC 的特异性和阳性预测值均高于 D-二聚体。TAT、PIC 和 D-二聚体的连续检测将特异性和阳性预测值分别提高到 90.91%[80.61%，96.25%]和 89.29%[77.45%，95.57%]。
联合检测 TAT 和 PIC 与 D-二聚体可能是监测有转移的癌症的有用的监测生物标志物。
