Tong F, Yang Y, Liang Y, Lopsong T Z, Liu Y L, Zhao S Q, He G L, Zhou Y W
Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hanyang Branch of Wuhan Public Security Bureau, Wuhan 430050, China.
Fa Yi Xue Za Zhi. 2020 Feb;36(1):99-103. doi: 10.12116/j.issn.1004-5619.2020.01.019.
The number of death from insulin overdose, including accidental poisoning, suicide and homicide, is increasing these years. The forensic diagnosis of death from insulin overdose is a tough task. Glucose is the main energy source of the brain. Therefore, hypoglycemic brain damage is considered to be the main reason of death from insulin overdose. Recently, research of hypoglycemic brain damage caused by insulin overdose is gradually being paid attention in the field of forensic medicine. This paper summarizes the neuropathologic changes, pathophysiologic process and potential neural molecular markers of hypoglycemic brain damage caused by insulin overdose in terms of forensic neuropathology, providing reference for the research and practice in forensic medicine related fields.
近年来，包括意外中毒、自杀和他杀在内的胰岛素过量致死人数呈上升趋势。胰岛素过量致死的法医学诊断是一项艰巨的任务。葡萄糖是大脑的主要能量来源。因此，低血糖脑损伤被认为是胰岛素过量致死的主要原因。近年来，胰岛素过量所致低血糖脑损伤的研究在法医学领域逐渐受到关注。本文从法医神经病理学角度总结胰岛素过量所致低血糖脑损伤的神经病理变化、病理生理过程及潜在的神经分子标志物，为法医学相关领域的研究和实践提供参考。
