Department of Surgical Sciences, University of Turin, Citta della Salute e della Scienza Hospital, Turin, Italy.
Rev Recent Clin Trials. 2021;16(1):22-31. doi: 10.2174/1574887115666200406121308.
Hemorrhoids are a common disease that is often considered an easy problem to solve. Unfortunately, some particular clinical conditions, including Inflammatory Bowel Diseases (IBD), pregnancy, immunosuppression, coagulopathy, cirrhosis with portal hypertension, and proctitis after radiotherapy, challenge hemorrhoids management and the outcomes.
Research and online contents related to hemorrhoids' treatment in special conditions are reviewed in order to help colorectal surgeons in daily practice.
There are very limited data about the outcomes of hemorrhoids treatment in these subgroups of patients. Patients in pregnancy can be effectively treated with medical therapy, reserving surgical intervention in highly selected and urgent cases. In case of thrombosed haemorrhoids, the excision allows a fast symptoms' resolution, with a low incidence of recurrence and a long remission interval. In case of immunosuppressed patients, there is no consensus for the best treatment, even in most HIV positive patients, a surgical procedure can be safely proposed when indicated. There is no sufficient data in the literature related to transplanted patients. The surgical treatment of hemorrhoids in patients with IBD, especially Crohn's Disease, can be unsafe, although there is a paucity of literature on this topic. In case of previous pelvic radiotherapy, it must always be considered that severe complications, like abscesses and fistulas with subsequent pelvic and retroperitoneal sepsis, can occur after surgical treatment of hemorrhoids, so a conservative treatment is advocated. Moreover, caution is recommended in treating patients with coagulopathy, considering possible complications (mostly bleeding) also after outpatient treatments. In case of portal hypertension and cirrhosis, a 'conservative treatment' is recommended. Bleeding hemorrhoids can be treated with hemorrhoidectomy when they do not respond to other treatments.
International literature is very scant about the treatment of patients affected by hemorrhoids in particular situations. A word of caution and concern even about the indication for minor outpatient procedures must be expressed in these patients, in order to avoid possible life-threatening complications. The first-line treatment is the conservative medical approach associated with the treatment of the primary disease.
痔疮是一种常见疾病,通常被认为是一个容易解决的问题。然而,一些特殊的临床情况,包括炎症性肠病(IBD)、妊娠、免疫抑制、凝血障碍、肝硬化伴门静脉高压和放疗后直肠炎,给痔疮的治疗和结果带来了挑战。
为了帮助肛肠外科医生在日常实践中,我们对与特殊情况下痔疮治疗相关的研究和在线内容进行了综述。
关于这些亚组患者痔疮治疗结果的数据非常有限。妊娠患者可以通过药物治疗有效治疗,仅在高度选择和紧急情况下保留手术干预。对于血栓性痔疮,切除可以快速缓解症状,复发率低,缓解间隔长。对于免疫抑制患者,目前尚无最佳治疗方法的共识,即使在大多数 HIV 阳性患者中,当指征明确时,也可以安全地提出手术治疗。关于移植患者,文献中没有足够的数据。对于 IBD 患者,尤其是克罗恩病患者,痔疮的手术治疗可能不安全,尽管关于这个主题的文献很少。对于先前接受过盆腔放疗的患者,必须始终考虑到在痔疮手术后可能会发生严重并发症,如脓肿和瘘管,随后可能会出现盆腔和腹膜后脓毒症,因此提倡保守治疗。此外,在治疗凝血障碍患者时要谨慎,因为即使在门诊治疗后也可能发生并发症(主要是出血)。对于门静脉高压和肝硬化,建议采取“保守治疗”。对于其他治疗方法无效的出血性痔疮,可以采用痔切除术治疗。
国际文献中关于在特殊情况下治疗患有痔疮的患者的内容非常有限。对于这些患者,即使是轻微的门诊手术的指征,也必须谨慎并表示关注,以避免可能危及生命的并发症。一线治疗是与治疗原发性疾病相关的保守药物治疗。