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Myocardial Energetics in Obesity: Enhanced ATP Delivery Through Creatine Kinase With Blunted Stress Response.肥胖患者心肌能量学:通过肌酸激酶增强 ATP 供应,同时压力反应减弱。
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2
Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity.预计美国各州成年人肥胖和重度肥胖的流行率。
N Engl J Med. 2019 Dec 19;381(25):2440-2450. doi: 10.1056/NEJMsa1909301.
3
Hemodynamic Effects of Weight Loss in Obesity: A Systematic Review and Meta-Analysis.肥胖患者体重减轻的血液动力学效应:系统评价和荟萃分析。
JACC Heart Fail. 2019 Aug;7(8):678-687. doi: 10.1016/j.jchf.2019.04.019. Epub 2019 Jul 10.
4
Evidence Supporting the Existence of a Distinct Obese Phenotype of Heart Failure With Preserved Ejection Fraction.支持射血分数保留的心力衰竭存在独特肥胖表型的证据。
Circulation. 2017 Jul 4;136(1):6-19. doi: 10.1161/CIRCULATIONAHA.116.026807. Epub 2017 Apr 5.
5
Abnormal right ventricular-pulmonary artery coupling with exercise in heart failure with preserved ejection fraction.射血分数保留的心力衰竭患者运动时右心室-肺动脉耦合异常。
Eur Heart J. 2016 Nov 14;37(43):3293-3302. doi: 10.1093/eurheartj/ehw241. Epub 2016 Jun 26.
6
Effects of catecholamine stress on diastolic function and myocardial energetics in obesity.儿茶酚胺应激对肥胖患者舒张功能和心肌能量代谢的影响。
Circulation. 2012 Mar 27;125(12):1511-9. doi: 10.1161/CIRCULATIONAHA.111.069518. Epub 2012 Feb 24.
7
Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction.射血分数保留的心力衰竭中的全球心血管储备功能障碍。
J Am Coll Cardiol. 2010 Sep 7;56(11):845-54. doi: 10.1016/j.jacc.2010.03.077.
8
Creatine kinase knockout mice show left ventricular hypertrophy and dilatation, but unaltered remodeling post-myocardial infarction.肌酸激酶基因敲除小鼠表现出左心室肥厚和扩张,但心肌梗死后重塑未改变。
Cardiovasc Res. 2005 Feb 1;65(2):419-27. doi: 10.1016/j.cardiores.2004.10.006.
9
Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart.衰竭的人类心脏中的心肌内脂质蓄积类似于脂毒性大鼠心脏。
FASEB J. 2004 Nov;18(14):1692-700. doi: 10.1096/fj.04-2263com.
10
Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women.肥胖和胰岛素抵抗对年轻女性心肌底物代谢及效率的影响。
Circulation. 2004 May 11;109(18):2191-6. doi: 10.1161/01.CIR.0000127959.28627.F8. Epub 2004 May 3.

Energetic Adaptations and Stress Reserve in the Obese Heart.

作者信息

Borlaug Barry A, Malloy Craig R

机构信息

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (B.A.B.).

Department of Internal Medicine and Advanced Imaging Research Center, University of Texas Southwestern, Dallas, TX (C.R.M.).

出版信息

Circulation. 2020 Apr 7;141(14):1164-1167. doi: 10.1161/CIRCULATIONAHA.120.045259. Epub 2020 Apr 6.

DOI:10.1161/CIRCULATIONAHA.120.045259
PMID:32250704
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7147721/
Abstract
摘要