Schäfer P, Fürrer C, Mermillod B
Department of Gynaecology, University Hospital of Geneva, Switzerland.
Int J Epidemiol. 1988 Dec;17(4):810-3. doi: 10.1093/ije/17.4.810.
In a series of 60 patients suffering from recurrent subareolar breast abscess (RSBA) heavy cigarette smoking was found at an unusually high frequency compared to a control group. In contrast with findings reported in the literature no relation was found with parity, oral contraceptive use or nipple retraction. The strong association of cigarette smoking and RSBA with a relative risk of 9.2 (3.6-23.5) for a light smoker and of 26.4 (9.9-70.2) for a heavy smoker counterbalances possible bias introduced by the retrospective analysis and by the hospital control group. The pathogenesis of RSBA is still not established. Cigarette smoking could have either a direct toxic effect on the retroareolar lactiferous ducts or an indirect effect via hormonal stimulation of the breast secretion; both hypotheses could explain the recurrent aspect of the disease.
在一组60例复发性乳晕下乳腺脓肿（RSBA）患者中，与对照组相比，发现重度吸烟的频率异常高。与文献报道的结果相反，未发现与产次、口服避孕药使用或乳头内陷有关。吸烟与RSBA之间存在强关联，轻度吸烟者的相对风险为9.2（3.6 - 23.5），重度吸烟者为26.4（9.9 - 70.2），这抵消了回顾性分析和医院对照组可能引入的偏差。RSBA的发病机制仍未明确。吸烟可能对乳晕后输乳管有直接毒性作用，也可能通过对乳腺分泌的激素刺激产生间接作用；这两种假设都可以解释该疾病的复发性。
