自身免疫性甲状腺疾病女性多囊卵巢综合征及其合并症的风险增加。
Increased Risk of Polycystic Ovary Syndrome and It's Comorbidities in Women with Autoimmune Thyroid Disease.
机构信息
Intelligent Diabetes Metabolism and Exercise Center, China Medical University Hospital, Taichung 40447 Taiwan.
School of Medicine, Institute of Medicine and Public Health, Chung Shan Medical University, Taichung 40201, Taiwan.
出版信息
Int J Environ Res Public Health. 2020 Apr 2;17(7):2422. doi: 10.3390/ijerph17072422.
OBJECTIVE
To investigate the prevalence of polycystic ovary syndrome (PCOS) and its comorbidities in patients with autoimmune thyroid disease (AITD).
POPULATION
In this cohort study, patients newly diagnosed as having Hashimoto thyroiditis (HT) or Grave disease (GD) were recruited into the AITD group.
METHOD
The logistic regression model was used to investigate the association between exposure, endpoint, later diseases and treatment.
MAIN OUTCOME MEASURES
We assessed the cumulative incidence using the Kaplan-Meier method and verified the difference by the log-rank test.
RESULTS
The AITD group included 3599 GD patients and 1332 HT patients. PCOS risk in patients with AITD was higher than that in the control group (adjusted hazard ratio = 1.39; 95% confidence interval = 1.07-1.71). In patients with both AITD and PCOS, the odds ratios of diabetes, hyperlipidemia and coronary artery disease were 2.48, 2.05 and 2.63, respectively.
CONCLUSIONS
The risks of PCOS and its comorbidities such as diabetes, dyslipidemia and cardiac artery disease are high in patients with AITD in Taiwan.
目的
探讨自身免疫性甲状腺疾病（AITD）患者多囊卵巢综合征（PCOS）及其合并症的患病率。
人群
在这项队列研究中，新诊断为桥本甲状腺炎（HT）或格雷夫斯病（GD）的患者被纳入 AITD 组。
方法
采用逻辑回归模型探讨暴露、终点、后续疾病和治疗之间的关联。
主要观察指标
采用 Kaplan-Meier 法评估累积发病率，并采用对数秩检验验证差异。
结果
AITD 组包括 3599 例 GD 患者和 1332 例 HT 患者。AITD 患者发生 PCOS 的风险高于对照组（校正后的危险比=1.39；95%置信区间=1.07-1.71）。在同时患有 AITD 和 PCOS 的患者中，糖尿病、高脂血症和冠状动脉疾病的比值比分别为 2.48、2.05 和 2.63。
结论
在台湾的 AITD 患者中，PCOS 及其合并症（如糖尿病、血脂异常和心血管疾病）的风险较高。
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