Kelly P M, McGovern M, Gatter K C, Theaker J M, McGee J O
University of Oxford, Nuffield Department of Pathology, John Radcliffe Hospital.
J Clin Pathol. 1988 Dec;41(12):1305-9. doi: 10.1136/jcp.41.12.1305.
A patient presented initially with a testicular mass, which on biopsy had morphological features consistent with malignant histiocytosis. The tumour cells labelled strongly with EBM/11, a murine monoclonal antibody with high specificity for cells of the human mononuclear phagocyte system. Subsequent clinical and laboratory studies confirmed the diagnosis. As poorly differentiated tumour cells reacted with EBM/11, this antibody may be useful in positively identifying malignant tumours with histiocytic differentiation from malignancies of other types where morphological detail alone is inconclusive in tumour classification.
一名患者最初表现为睾丸肿块，活检显示其形态学特征与恶性组织细胞增多症相符。肿瘤细胞与EBM/11强烈结合，EBM/11是一种对人单核吞噬细胞系统细胞具有高特异性的鼠单克隆抗体。随后的临床和实验室研究证实了诊断。由于低分化肿瘤细胞与EBM/11发生反应，该抗体可能有助于从形态学细节在肿瘤分类中单独无法确定的其他类型恶性肿瘤中阳性识别具有组织细胞分化的恶性肿瘤。
