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比较几种专用乳腺术中电子放射治疗放射防护盘的性能:一项蒙特卡罗研究。

Comparing the performance of some dedicated radioprotection disks in breast intraoperative electron radiotherapy: a Monte Carlo study.

机构信息

Physics Department, Hakim Sabzevari University, Sabzevar, Iran.

Medical Physics and Radiological Sciences Department, Sabzevar University of Medical Sciences, Sabzevar, Iran.

出版信息

Radiat Environ Biophys. 2020 May;59(2):265-281. doi: 10.1007/s00411-020-00836-z. Epub 2020 Apr 6.

DOI:10.1007/s00411-020-00836-z
PMID:32253497
Abstract

Radiation-shielding of healthy tissue is mandatory in breast intraoperative electron radiotherapy (IOERT). In this regard, dedicated radioprotection disks have been introduced. The aim of this study was to evaluate and compare the performance of three radioprotection disks widely used for breast IOERT. A Monte Carlo simulation approach was used for this purpose. The considered disks included Al + Pb, PMMA + Copper, and PTFE + Steel. They were stimulated by means of the MCNPX Monte Carlo code at depths around R and R of different electron energies in a water phantom, and their impact on the dosimetric properties of the therapeutic beam was evaluated in both correct and upside down disk placements. The electron energy spectrum immediately above and below each disk was calculated and analyzed. Furthermore, performance characteristics of the studied disks such as backscatter factors (BSFs) and transmission factors (TFs) at different electron energies were determined and compared. The results show that the Al + Pb disk most effectively attenuates the beam, while at the same time exhibits maximum BSF values. Employing the PMMA + Copper disk can minimize the BSF value but at the expense of an increased TF. The Al + Pb disk showed the best performance from the radiation protection viewpoint, while its highest BSF values could lead to perturbation of dose homogeneity within the target volume. PTFE + Steel disk showed an intermediate performance regarding the electron backscattering and transmission among the studied disks. The reverse placement of each disk can substantially increase the BSF value as compared to the correct situation but had less impact on the TF value.

摘要

健康组织的辐射防护在术中电子放射治疗(IOERT)中是强制性的。为此,已经引入了专用的放射防护盘。本研究的目的是评估和比较三种广泛用于乳房 IOERT 的放射防护盘的性能。为此目的使用了蒙特卡罗模拟方法。所考虑的磁盘包括 Al+Pb、PMMA+铜和 PTFE+钢。在水模体中,用 MCNPX 蒙特卡罗代码在 R 和不同电子能量的 R 附近的深度对这些磁盘进行了模拟,并评估了它们在正确和颠倒的磁盘放置方式下对治疗束剂量特性的影响。计算并分析了每个磁盘上方和下方的电子能谱。此外,还确定并比较了研究磁盘的性能特征,例如不同电子能量下的反向散射因子(BSF)和传输因子(TF)。结果表明,Al+Pb 磁盘最有效地衰减了射束,同时表现出最大的 BSF 值。使用 PMMA+铜磁盘可以最小化 BSF 值,但代价是 TF 值增加。从辐射防护的角度来看,Al+Pb 磁盘的性能最好,但其最高的 BSF 值可能会导致靶区内部剂量均匀性的波动。PTFE+钢磁盘在研究磁盘的电子反向散射和传输方面表现出中等性能。与正确情况相比,每个磁盘的反向放置会大大增加 BSF 值,但对 TF 值的影响较小。

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本文引用的文献

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Monte Carlo-based determination of radiation leakage dose around a dedicated IOERT accelerator.基于蒙特卡罗方法测定专用术中电子放射治疗加速器周围的辐射泄漏剂量。
Radiat Environ Biophys. 2019 May;58(2):263-276. doi: 10.1007/s00411-019-00786-1. Epub 2019 Apr 10.
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Shielding disk position in intra-operative electron radiotherapy (IOERT): A Monte Carlo study.术中电子放射治疗(IOERT)中的屏蔽盘位置:蒙特卡罗研究。
Phys Med. 2018 Jul;51:1-6. doi: 10.1016/j.ejmp.2018.05.023. Epub 2018 Jun 15.
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Intraoperative Electron Radiotherapy (IOERT) in the Treatment of Primary Breast Cancer.
术中电子放疗(IOERT)在原发性乳腺癌治疗中的应用
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Comparison of Local Recurrence Among Early Breast Cancer Patients Treated With Electron Intraoperative Radiotherapy vs Hypofractionated Photon Radiotherapy an Observational Study.早期乳腺癌患者术中电子放疗与大分割光子放疗局部复发情况的比较:一项观察性研究
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Monte Carlo Simulation of Electron Beams produced by LIAC Intraoperative Radiation Therapy Accelerator.LIAC术中放射治疗加速器产生的电子束的蒙特卡罗模拟
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Intraoperative Radiotherapy for Breast Cancer.乳腺癌术中放疗
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Commissioning of beam shaper applicator for conformal intraoperative electron radiotherapy.用于术中适形电子放疗的射束整形器施源器的调试
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Comparing the dosimetric characteristics of the electron beam from dedicated intraoperative and conventional radiotherapy accelerators.比较专用术中放疗加速器和传统放疗加速器产生的电子束的剂量学特征。
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In vivo dosimetry and shielding disk alignment verification by EBT3 GAFCHROMIC film in breast IOERT treatment.在乳腺术中电子束放射治疗中,使用EBT3 GAFCHROMIC薄膜进行体内剂量测定和屏蔽盘对准验证。
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