Ekkelenkamp Antonie E, Elzes M Rachèl, Engbersen Johan F J, Paulusse Jos M J
Department of Biomolecular Nanotechnology, MESA+ Institute for Nanotechnology, Faculty of Science and Technology, University of Twente, P. O. Box 217, 7500 AE, Enschede, The Netherlands.
J Mater Chem B. 2018 Jan 14;6(2):210-235. doi: 10.1039/c7tb02239e. Epub 2017 Dec 6.
Water-soluble, nano-sized crosslinked polymer networks, or nanogels, are delivery vehicles, which have highly interesting properties for therapeutic delivery and imaging. Nanogels may also possess responsive properties, depending on the employed polymers, allowing controlled release of therapeutics or image contrast generation upon exposure to physical or (bio)chemical cues. In this review, polymer nanogels are explored for application in imaging as well as for controlled drug and gene delivery. Moreover, nanogels are explored as responsive biomaterials and future applications are highlighted.
水溶性纳米级交联聚合物网络，即纳米凝胶，是一种递送载体，在治疗递送和成像方面具有非常有趣的特性。根据所使用的聚合物，纳米凝胶也可能具有响应特性，能够在受到物理或（生物）化学信号刺激时实现治疗剂的控释或产生图像对比度。在本综述中，探讨了聚合物纳米凝胶在成像以及药物和基因控释方面的应用。此外，还探讨了纳米凝胶作为响应性生物材料的应用，并强调了其未来的应用前景。
