Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, Shanxi 030001, China.
Center for Human Tissue and Organs Degeneration and Shenzhen Key Laboratory of Marine Biomedical Materials, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China.
Int J Biol Macromol. 2023 Dec 31;253(Pt 6):127149. doi: 10.1016/j.ijbiomac.2023.127149. Epub 2023 Sep 29.
In biomedical engineering, smart materials act as media to communicate physiological signals inspired by environmentally responsive stimuli with outer indicators for timely scrutiny and precise therapy. Various physical and chemical processes are applied in the design of specific smart functions. Hydrogels are polymeric networks consisting of hydrophilic chains and chemical groups and they have contributed their unique features in biomedical application as one of the most used smart materials. Numerous raw materials can form hydrogels, in which cellulose and its derivatives have been extensively exploited in biomedicine due to their high hydrophilicity, availability, renewability, biodegradability, biocompatibility, and multifunctional reactivity. This review collates cellulose-based hydrogels and their extensive applications in the biomedical domain, specifically benefiting from the "SMART" concept in their design, synthesis and device assembly. The first section discusses the physical and chemical crosslinking and electrospinning techniques used in the fabrication of smart cellulose-based hydrogels. The second section describes the performance of these hydrogels, and the final section is a comprehensive discussion of their biomedical applications.
在生物医学工程中，智能材料作为介质，将受环境响应刺激启发的生理信号与外部指示剂进行通讯，以便及时检查和精确治疗。在设计特定的智能功能时，应用了各种物理和化学过程。水凝胶是由亲水链和化学基团组成的聚合物网络，作为最常用的智能材料之一，它们在生物医学应用中具有独特的特性。许多原材料可以形成水凝胶，其中纤维素及其衍生物由于其高亲水性、可用性、可再生性、可生物降解性、生物相容性和多功能反应性而在生物医学中得到了广泛的应用。本综述总结了基于纤维素的水凝胶及其在生物医学领域的广泛应用，特别是得益于其设计、合成和器件组装中的“SMART”概念。第一节讨论了用于制备智能纤维素基水凝胶的物理和化学交联以及静电纺丝技术。第二节描述了这些水凝胶的性能，最后一节是对其生物医学应用的综合讨论。
