Massaro Marina, Cavallaro Giuseppe, Colletti Carmelo G, Lazzara Giuseppe, Milioto Stefana, Noto Renato, Riela Serena
Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Viale delle Scienze, Ed. 17, 90128 Palermo, Italy.
J Mater Chem B. 2018 Jun 7;6(21):3415-3433. doi: 10.1039/c8tb00543e. Epub 2018 Apr 30.
Clay minerals have been used for medical purposes from ancient times. Among them, the halloysite nanotube, an aluminosilicate of the kaolin group, is an emerging nanomaterial which possesses peculiar chemical characteristics. By means of suitable modifications, such as supramolecular functionalization or covalent modifications, it is possible to obtain novel nanomaterials with tunable properties for several applications. In this context the covalent grafting of suitable organic moieties on the external surface or in the halloysite lumen has been exploited to improve the loading and release of several biologically active molecules. The resulting hybrid nanomaterials have been applied as drug carrier and delivery systems, as fillers for hydrogels, in tissue regeneration and in the gene delivery field. Furthermore the loading and release of specific molecules have been also investigated for environmental purposes. This review summarizes the main developments in the halloysite modifications in the last 20 years with a particular attention to the development in the past two years.
从古代起，粘土矿物就被用于医疗目的。其中，埃洛石纳米管是高岭土族的一种铝硅酸盐，是一种新兴的纳米材料，具有独特的化学特性。通过适当的修饰，如超分子功能化或共价修饰，可以获得具有可调性质的新型纳米材料，用于多种应用。在这种情况下，已利用在埃洛石外表面或管腔内共价接枝合适的有机部分来改善几种生物活性分子的负载和释放。所得的杂化纳米材料已被用作药物载体和递送系统、水凝胶的填料、用于组织再生以及基因递送领域。此外，还针对环境目的研究了特定分子的负载和释放。本综述总结了过去20年中埃洛石修饰的主要进展，特别关注过去两年的进展。
