Du Qing, Li Ling, Liu Yiming, Zeng Jian, Li Jianye, Zheng Chuansheng, Zhou Guofeng, Yang Xiangliang
National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China.
J Mater Chem B. 2018 Jun 7;6(21):3522-3530. doi: 10.1039/c8tb00542g. Epub 2018 May 17.
A new one-step electrospraying method is developed to fabricate intrinsic X-ray imaging barium alginate microspheres loaded with in situ synthesized BaSO particles (BaSO@BaAlg microspheres). The electrospraying method is straightforward and environmentally friendly, involving only the aqueous phase without any extra surfactant. It is also flexible. By varying the parameters of electrospraying, monodispersed BaSO@BaAlg microspheres with a diameter range from 200 to 1800 μm are achieved and meet the requirements for precisely calibrated embolics and flexible clinical applications. BaSO@BaAlg microspheres possess long-term X-ray imaging capability, which shows their own location and distribution precisely in real time during transcatheter arterial embolization operations, and they can be used for noninvasive examinations after operations. The in vitro X-ray-visible stability test demonstrates that the X-ray imaging capability of the BaSO@BaAlg microspheres is extremely stable. The fluctuation of radiodensity is within 7% of its original value over 52 days. Furthermore, the digital radiography and computed tomography images of a renal artery embolized with the BaSO@BaAlg microspheres confirm that in vivo visibility under X-ray is kept constant for an embolization period of 3 weeks. Angiographic and histological studies on an embolized kidney verify that the microspheres completely occlude the blood vessels of the targeted kidney, including peripheral vessels.
一种新的一步电喷雾法被开发用于制备负载原位合成硫酸钡颗粒的本征X射线成像海藻酸钡微球（BaSO@BaAlg微球）。该电喷雾法简单直接且环保，仅涉及水相，无需任何额外的表面活性剂。它还具有灵活性。通过改变电喷雾参数，可获得直径范围为200至1800μm的单分散BaSO@BaAlg微球，满足精确校准栓塞剂和灵活临床应用的要求。BaSO@BaAlg微球具有长期X射线成像能力，在经导管动脉栓塞手术过程中能实时精确显示其自身位置和分布，并且术后可用于无创检查。体外X射线可见稳定性测试表明，BaSO@BaAlg微球的X射线成像能力极其稳定。在52天内，射线密度波动在其原始值的7%以内。此外，用BaSO@BaAlg微球栓塞肾动脉的数字射线摄影和计算机断层扫描图像证实，在3周的栓塞期内，X射线下的体内可见性保持不变。对栓塞肾脏的血管造影和组织学研究证实，微球完全阻塞了目标肾脏的血管，包括外周血管。
