CAS Key Laboratory of Magnetic Materials and Devices, Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, & Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, P. R. China.
J Mater Chem B. 2019 Jan 14;7(2):210-223. doi: 10.1039/c8tb02704h. Epub 2018 Dec 13.
The development of a simplified theranostic system with high-efficiency for multifunctional imaging-guided photodynamic therapy/photothermal therapy (PDT/PTT) is a great challenge. Therefore, a versatile fabrication strategy was introduced to design new FeO-black TiO nanocomposites (Fe-Ti NCs). The Fe-Ti NCs exhibit an intense broad light absorption, high photothermal conversion efficiency, inherited phototherapy, and favorable magnetic resonance imaging (MRI) properties. The in vitro results demonstrate synergistic PTT and PDT capability of Fe-Ti NCs under 808 nm irradiation at low concentration and power density. Fe-Ti NCs also show superior phototherapy performance (PTT/PDT) under 671 nm laser irradiation. The confocal microscopy analysis demonstrates reactive oxygen species (ROS)-mediated synergistic phototherapy. Hematological and histological analysis confirms no evident toxicity of Fe-Ti NCs. The in vivo photoinduced tumor ablation capability of Fe-Ti NCs was assessed and monitored, and a rapid increase in temperature (60 ± 2 °C) after being exposed to 808 nm laser at 0.7 W cm for 5 min was observed. Then, the same change in temperature is observed under 671 nm laser at 0.5 W cm. Thus, in vitro and in vivo dual-wavelength laser tumor ablation ability of Fe-Ti NCs verified excellent synergistic phototherapy efficacy against tumors. Moreover, Fe-Ti NCs exhibit superparamagnetic behavior, high magnetization value (48 emu g), good r relaxivity value (38.2 mM s), and excellent T imaging capability to monitor therapeutic performance.
开发具有高效多功能成像引导光动力治疗/光热治疗（PDT/PTT）的简化治疗系统是一个巨大的挑战。因此，引入了一种通用的制造策略来设计新型 FeO-黑 TiO 纳米复合材料（Fe-Ti NCs）。Fe-Ti NCs 表现出强烈的宽光吸收、高光热转换效率、继承的光疗和良好的磁共振成像（MRI）特性。体外结果表明，在低浓度和低功率密度下，808nm 照射下 Fe-Ti NCs 具有协同的 PTT 和 PDT 能力。Fe-Ti NCs 在 671nm 激光照射下也表现出优异的光疗性能（PTT/PDT）。共聚焦显微镜分析表明 ROS 介导的协同光疗。血液学和组织学分析证实了 Fe-Ti NCs 没有明显的毒性。评估并监测了 Fe-Ti NCs 的体内光诱导肿瘤消融能力，在暴露于 808nm 激光 5 分钟、功率密度为 0.7W/cm 时，观察到温度迅速升高（60±2°C）。然后，在 671nm 激光下观察到相同的温度变化，功率密度为 0.5W/cm。因此，Fe-Ti NCs 的体外和体内双波长激光肿瘤消融能力验证了对肿瘤的优异协同光疗效果。此外，Fe-Ti NCs 表现出超顺磁性、高磁化值（48 emu/g）、良好的 r 弛豫率值（38.2mM/s）和优异的 T 成像能力，可用于监测治疗效果。
