Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, The First Affiliated Hospital, University of Science and Technology of China, Hefei 230026, P. R. China.
J Mater Chem B. 2019 Mar 28;7(12):2032-2042. doi: 10.1039/c8tb03148g. Epub 2019 Feb 21.
Development of near infrared (NIR) light-responsive nanomaterials for high performance multimodal phototherapy within a single nanoplatform is still challenging in technology and biomedicine. Herein, a new phototherapeutic nanoagent based on FDA-approved Prussian blue (PB) functionalized oxygen-deficient molybdenum oxide nanoparticles (MoO NPs) is strategically designed and synthesized by a facile one-pot size/morphology-controlled process. The as-prepared PB-MoO nanocomposites (NCs) with a uniform particle size of ∼90 nm and high water dispersibility exhibited strong optical absorption in the first biological window, which is induced by plasmon resonance in an oxygen-deficient MoO semiconductor. More importantly, PB-MoO NCs not only exhibited a high photothermal conversion efficiency of ∼63.7% and photostability but also offered a further approach for the generation of reactive oxygen species (ROS) upon singular NIR light irradiation which significantly improved the therapeutic efficiency of the PB agent. Furthermore, PB-MoO NCs showed a negligible cytotoxic effect in the dark, but an excellent therapeutic effect toward two triple-negative breast cancer (TNBC) cell lines at a low concentration (20 μg mL) of NCs and a moderate NIR laser power density. Additionally, efficient tumor ablation and metastasis inhibition in a 4T1 TNBC mouse tumor model can also be realized by synergistic photothermal/photodynamic therapy (PTT/PDT) under a single continuous NIR wave laser. Taken together, this study paved the way for the use of a single nanosystem for multifunctional therapy.
在单一纳米平台内开发用于高性能多模式光疗的近红外（NIR）光响应纳米材料在技术和生物医学方面仍然具有挑战性。在此，通过简便的一锅法尺寸/形貌可控工艺，策略性地设计并合成了基于经美国食品和药物管理局（FDA）批准的普鲁士蓝（PB）功能化缺氧气态氧化钼纳米粒子（MoO NPs）的新型光疗纳米制剂。所制备的具有均匀粒径约为 90nm 和高水分散性的 PB-MoO 纳米复合材料（NCs）在第一生物窗口中表现出强的光吸收，这是由缺氧气态 MoO 半导体中的等离子体共振引起的。更重要的是，PB-MoO NCs 不仅表现出高达 63.7%的高光热转换效率和光稳定性，而且在单一 NIR 光照射下还进一步产生了活性氧物种（ROS），这显著提高了 PB 试剂的治疗效率。此外，PB-MoO NCs 在黑暗中几乎没有细胞毒性，但在 NCs 的低浓度（20μgmL）和适度的 NIR 激光功率密度下，对两种三阴性乳腺癌（TNBC）细胞系表现出优异的治疗效果。此外，在 4T1 TNBC 小鼠肿瘤模型中，还可以通过协同光热/光动力疗法（PTT/PDT）在单一连续 NIR 波激光下实现有效的肿瘤消融和转移抑制。综上所述，该研究为多功能治疗的单一纳米系统的应用铺平了道路。
