简便组装新型聚吡咯纳米复合材料诊疗剂用于磁共振和计算机断层成像引导的肿瘤高效光热消融。
Facile assembling of novel polypyrrole nanocomposites theranostic agent for magnetic resonance and computed tomography imaging guided efficient photothermal ablation of tumors.
机构信息
College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.
College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.
出版信息
J Colloid Interface Sci. 2018 Nov 15;530:547-555. doi: 10.1016/j.jcis.2018.07.001. Epub 2018 Jul 2.
Multifunctional nanocomposites for image-guided cancer therapy are highly desired in clinical application. Herein, a novel theranostic agent based on gold and ferroferric oxide nanoparticles coating polypyrrole particles (PPy@FeO/Au nanocomposites) for computed tomography (CT) and magnetic resonance (MR) imaging guided photothermal therapy was successfully assembled by a very facile electrostatic adsorption method. PPy@FeO/Au nanocomposites exhibit good biocompatibility in vitro and in vivo. Because of high r relaxivity of FeO and high X-ray attenuation ability of Au, the PPy@FeO/Au nanocomposites exhibited desirable CT and MR imaging performance, which provide more comprehensive and accurate diagnostic information. Moreover, PPy@FeO/Au nanocomposites can efficiently kill cancer cells by hyperthermia with the guiding of CT and MR imaging, even completely ablate tumours. Hence, the electrostatic adsorption assembled PPy@FeO/Au nanocomposites have great potential in clinical application for diagnosing and treating tumour in the future.
多功能纳米复合材料在癌症的影像引导治疗中具有很大的临床应用需求。在此，我们通过一种非常简便的静电吸附方法，成功组装了一种基于金和四氧化三铁纳米粒子包覆聚吡咯颗粒的诊疗一体化试剂（PPy@FeO/Au 纳米复合材料），用于计算机断层扫描（CT）和磁共振（MR）成像引导光热治疗。PPy@FeO/Au 纳米复合材料在体外和体内均表现出良好的生物相容性。由于 FeO 的弛豫率高和 Au 的 X 射线衰减能力强，PPy@FeO/Au 纳米复合材料表现出了理想的 CT 和 MR 成像性能，为肿瘤的诊断提供了更全面、更准确的信息。此外，在 CT 和 MR 成像的引导下，PPy@FeO/Au 纳米复合材料可以通过热疗有效地杀死癌细胞，甚至可以完全消融肿瘤。因此，静电吸附组装的 PPy@FeO/Au 纳米复合材料在未来的肿瘤诊断和治疗方面具有很大的临床应用潜力。
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