一种用于癌症光热/光动力联合治疗的钯花冠-人血清白蛋白-吲哚菁绿纳米复合材料。
A Pd corolla-human serum albumin-indocyanine green nanocomposite for photothermal/photodynamic combination therapy of cancer.
作者信息
Sun Duo, Huang Yizhuan, Zhang Xianhua, Peng Jian, Li Jingchao, Ming Jiang, Wei Jingping, Chen Xiaolan, Zheng Nanfeng
机构信息
State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, National & Local Joint Engineering Research Center of Preparation Technology of Nanomaterials, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
出版信息
J Mater Chem B. 2018 Nov 21;6(43):6969-6976. doi: 10.1039/c8tb01874j. Epub 2018 Oct 16.
In this work, a novel nanoplatform based on Pd corolla-human serum albumin-indocyanine green (PdCs-HSA-ICG) was developed for cancer photothermal/photodynamic combination therapy. Pd corollas (denoted as PdCs) with good near-infrared photothermal conversion efficiency (η≈ 37%) were first prepared and modified with human serum albumin (HSA) and indocyanine green (ICG) to get the PdCs-HSA-ICG nanocomposite. The prepared PdCs-HSA-ICG not only improves the colloid and thermal stability of ICG, but also shows a higher temperature increase than that of PdCs and free ICG as well as a comparable singlet oxygen (O) generation capability to that of free ICG. Upon single 808 nm laser irradiation, the photothermal (PTT)/photodynamic (PDT) combined therapeutic efficacy of PdCs-HSA-ICG at both cellular and animal levels was superior to PdCs-HSA (PTT) or free ICG (PTT and PDT), respectively. Thus, the designed PdCs-HSA-ICG nanocomposite holds great potential as a new class of photosensitive agent for cancer phototherapy.
在本研究中，开发了一种基于钯花冠-人血清白蛋白-吲哚菁绿（PdCs-HSA-ICG）的新型纳米平台用于癌症光热/光动力联合治疗。首先制备了具有良好近红外光热转换效率（η≈37%）的钯花冠（记为PdCs），并用人类血清白蛋白（HSA）和吲哚菁绿（ICG）对其进行修饰，得到PdCs-HSA-ICG纳米复合材料。所制备的PdCs-HSA-ICG不仅提高了ICG的胶体稳定性和热稳定性，而且与PdCs和游离ICG相比，显示出更高的升温效果，并且与游离ICG具有相当的单线态氧（O）生成能力。在单次808 nm激光照射下，PdCs-HSA-ICG在细胞和动物水平上的光热（PTT）/光动力（PDT）联合治疗效果分别优于PdCs-HSA（PTT）或游离ICG（PTT和PDT）。因此，所设计的PdCs-HSA-ICG纳米复合材料作为一类新型的癌症光疗光敏剂具有巨大的潜力。
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