College of Materials Science and Engineering, Hunan University, Changsha, China.
Department of Chemistry, Xiamen University, Xiamen, China.
Theranostics. 2020 Aug 8;10(22):10057-10074. doi: 10.7150/thno.45990. eCollection 2020.
In recent decade, palladium-based (Pd-based) nanomaterials have shown significant potential for biomedical applications because of their unique optical properties, excellent biocompatibility and high stability in physiological environment. Compared with other intensively studied noble nanomaterials, such as gold (Au) and silver (Ag) nanomaterials, research on Pd-based nanomaterials started late, but the distinctive features, such as high photothermal conversion efficiency and high photothermal stability, have made them getting great attention in the field of nanomedicine. The goal of this review is to provide a comprehensive and critical perspective on the recent progress of Pd-based nanomaterials as imaging contrast agents and therapeutic agents. The imaging section focuses on applications in photoacoustic (PA) imaging, single-photon emission computed tomography (SPECT) imaging, computed tomography (CT) imaging and magnetic resonance (MR) imaging. For treatment of cancer, single photothermal therapy (PTT) and PTT combined with other therapeutic modalities will be discussed. Finally, the safety concerns, forthcoming challenges and perspective of Pd-based nanomaterials on biomedical applications will be presented.
在过去的十年中，钯基（Pd-based）纳米材料由于其独特的光学性质、优异的生物相容性和在生理环境中的高稳定性，在生物医学应用中显示出了巨大的潜力。与其他受到广泛研究的贵金属纳米材料（如金（Au）和银（Ag）纳米材料）相比，Pd 基纳米材料的研究起步较晚，但由于其独特的高光热转换效率和高光热稳定性等特点，在纳米医学领域引起了广泛关注。本综述的目的是提供对 Pd 基纳米材料作为成像对比剂和治疗剂的最新进展的全面和批判性的综述。成像部分重点介绍了在光声（PA）成像、单光子发射计算机断层扫描（SPECT）成像、计算机断层扫描（CT）成像和磁共振（MR）成像中的应用。对于癌症的治疗，将讨论单光热疗法（PTT）和 PTT 联合其他治疗方式。最后，将介绍 Pd 基纳米材料在生物医学应用中的安全性问题、未来的挑战和前景。
