Zhao Tiancong, Chen Liang, Li Qin, Li Xiaomin
Laboratory of Advanced Materials, State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Chemistry for Energy Materials (2011-iChEM), Fudan University, Shanghai 200433, P. R. China.
J Mater Chem B. 2018 Nov 28;6(44):7112-7121. doi: 10.1039/c8tb01548a. Epub 2018 Aug 1.
Stimuli triggered drug delivery systems enable controlled release of drugs at the optimal space and time, thus achieving optimal therapeutic effects. As one of the most important stimuli used in bioapplications, near-infrared (NIR) light possesses unique advantages such as deep tissue penetration with minimum auto-fluorescence & tissue scattering and high biosafety. Mesoporous silica nanoparticles (MSNs) are one of the most studied nanocarriers; apart from having a high surface area and large pore volume for loading of drugs, they can be easily functionalized with inorganic nanomaterials and stimuli responsive polymers or organic switch molecules, creating possibilities for designing complex stimuli triggered drug delivery systems. Considering the high tissue penetration depth of NIR light and the unique mesoporous structure of MSNs, NIR responsive inorganic nanoparticle functionalized MSNs can be further combined with stimuli responsive materials to form smart "nano-devices" for controlled drug delivery toward tumors, and to date much progress has been made. In this article, recent advances in the design of NIR triggered mesoporous silica drug delivery systems are systematically summarized and some outstanding studies are highlighted. We will also discuss the shortcomings, challenges and opportunities in the field.
刺激触发型药物递送系统能够在最佳的空间和时间实现药物的控释，从而达到最佳治疗效果。作为生物应用中最重要的刺激因素之一，近红外（NIR）光具有独特的优势，如能以最小的自体荧光和组织散射实现深层组织穿透以及高生物安全性。介孔二氧化硅纳米颗粒（MSNs）是研究最多的纳米载体之一；除了具有高比表面积和大孔体积以用于药物负载外，它们还可以很容易地用无机纳米材料、刺激响应性聚合物或有机开关分子进行功能化，为设计复杂的刺激触发型药物递送系统创造了可能性。考虑到近红外光的高组织穿透深度以及介孔二氧化硅纳米颗粒独特的介孔结构，近红外响应性无机纳米颗粒功能化的介孔二氧化硅纳米颗粒可以进一步与刺激响应性材料结合，形成用于向肿瘤进行控释给药的智能“纳米装置”，并且迄今为止已经取得了很大进展。在本文中，我们系统地总结了近红外触发介孔二氧化硅药物递送系统设计方面的最新进展，并突出了一些杰出的研究。我们还将讨论该领域的缺点、挑战和机遇。
