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大分子硫化氢前药的益处。

The benefits of macromolecular hydrogen sulfide prodrugs.

作者信息

Connal Luke A

机构信息

Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia.

出版信息

J Mater Chem B. 2018 Nov 28;6(44):7122-7128. doi: 10.1039/c8tb02352b. Epub 2018 Nov 5.

DOI:10.1039/c8tb02352b
PMID:32254628
Abstract

Hydrogen sulfide has significant therapeutic potential that is continually being implicated in a variety of biochemical processes. This highlight article will present the benefits and opportunities in designing macromolecule based HS donors. Emphasis will be on how design of polymer systems can help drive the development of HS therapeutics. With a better range of donor systems this field will progress rapidly and new applications for HS therapeutics will be discovered.

摘要

硫化氢具有巨大的治疗潜力,且不断被证明参与多种生化过程。这篇重点文章将介绍设计基于大分子的硫化氢供体的益处和机遇。重点将放在聚合物体系的设计如何有助于推动硫化氢疗法的发展上。有了更广泛的供体体系,该领域将迅速发展,并将发现硫化氢疗法的新应用。

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