Ma Yan, Chen Huajian, Hao Baimei, Zhou Junhong, He Gang, Miao Zhaohua, Xu Yan, Gao Li, Zhou Wei, Zha Zhengbao
School of Biological and Medical Engineering, Hefei University of Technology, Hefei, Anhui 230009, P. R. China.
J Mater Chem B. 2018 Oct 7;6(37):5854-5859. doi: 10.1039/c8tb01987h. Epub 2018 Aug 30.
Insufficient and heterogeneously distributed heat commonly leads to the incomplete elimination and recurrence of tumors. Inspired by the fact that autophagy is essential for cell survival in response to harmful stresses, a near-infrared (NIR) light responsive chloroquine (CQ, a well-known autophagy inhibitor) delivery system, consisting of phase-changing material (1-tetradecanol, PCM) and hollow mesoporous Prussian blue nanoparticles (HMPBs), is reported here to deliver CQ to the tumor region to augment the efficacy of photothermal therapy (PTT). In vitro thermosensitive CQ release assays demonstrated that precise "on-off" release profiles of CQ could be readily manipulated, owing to the excellent photothermal conversion abilities of HMPBs and the solid-to-liquid phase change properties of the PCM under NIR light illumination. Furthermore, targeted autophagy inhibition in cancer cells could remarkably amplify the cell-killing efficiency of PTT, leading to synergistic cancer suppression at mild therapeutic temperatures. Therefore, this work is expected to depict an effective strategy for the design and construction of a thermally responsive CQ delivery platform for modulating autophagy inhibition in tumors to reinforce the efficacy of PTT.
热量不足且分布不均通常会导致肿瘤无法被完全消除并复发。鉴于自噬对于细胞在应对有害应激时的存活至关重要，本文报道了一种近红外（NIR）光响应性氯喹（CQ，一种著名的自噬抑制剂）递送系统，该系统由相变材料（1-十四醇，PCM）和中空介孔普鲁士蓝纳米颗粒（HMPBs）组成，可将CQ递送至肿瘤区域以增强光热疗法（PTT）的疗效。体外热敏CQ释放试验表明，由于HMPBs具有出色的光热转换能力以及PCM在近红外光照射下的固-液相变特性，CQ的精确“开-关”释放曲线易于操控。此外，对癌细胞进行靶向自噬抑制可显著提高PTT的细胞杀伤效率，从而在温和的治疗温度下实现协同抗癌作用。因此，这项工作有望描绘出一种有效的策略，用于设计和构建热响应性CQ递送平台，以调节肿瘤中的自噬抑制作用，从而增强PTT的疗效。
